The zwitterionic membranes showed minimal protein adsorption and a very low degree of protein fouling over a wide range of conditions with all proteins, including conditions where the protein and membrane were oppositely charged. These results provide important insights into the low fouling characteristics of zwitterionic ultrafiltration membranes. (C)

2013 Elsevier B.V. All rights reserved.”
“This paper presents the first comprehensive report of the organochlorine pesticide residues (OCs) such as hexachlorocyclohexane isomers (HCHs), dichlorodiphenyltrichloroethane and its six metabolites (DDTs), and hexachlorobenzene (HCB) in core sediments (< 63-mu m particle size) from the Indian Sunderban wetland. The pooled mean values of the mass fraction of Sigma HCHs, SBC-115076 chemical structure HCB, and Sigma DDTs in the sediments were 0.05-12, 0.05-1.4, and 0.05-11.5 ng g(-1) dry weight, respectively. The vertical distribution of pesticides reveals an erratic pattern. The concentration of four isomers of HCHs reveals a heterogenic distribution where gamma-HCH (lindane) and beta-HCH shared the dominant part. The mass fraction of HCB did not show any sharp spatial variation. The prevailing sequence of DDT metabolites indicates an active degradation

of the parent compound in the sediments and/or inputs of already degraded pp’DDT to the region. Peak concentrations of HCH isomers and DDT metabolites have the potential to induce ecotoxicological impact as per the check details sediment quality guidelines.”
“Motor overflow refers to involuntary movement or muscle activity that may coincide with voluntary movement. This study examined factors influencing motor overflow in 17 children

(8-11 years), and 17 adults (18-35 years). Participants performed a finger pressing task by exerting either 33% or 66% of their maximal force output using their dominant or non-dominant hand. Attention was manipulated by tactile stimulation to one or both hands. Overflow relative to the target force was greater in children compared to adults, and at the lower target force for both groups, but was not influenced by attentional stimulation. Childhood overflow was greater when the left-hand performed the task. Although an immature motor system may underlie an inability to suppress involuntary movement, childhood overflow may provide motor stabilization. Crown Copyright (C) CAL-101 nmr 2008 Published by Elsevier Inc. All rights reserved.”
“Fullerene and their derivatives have many potential new applications. However, there is increasing concern regarding toxicity as very little information is available about fullerene derivatives-protein interactions. In the present work, to identify proteins interacting with chiral fullerene derivatives, Potential Drug Target Database was searched using reverse docking approach. Hypoxanthine phosphoribosyltransferase and Beta-secretase-1 were found to be the most favorable protein targets for fullerene derivatives.

Conclusion Increased pHR acutely reduces MSNA BMS-777607 and improves haemodynamics

in HF patients treated with CRT with no evident differences between BiV- and AAI-pacing modes. Further studies are warranted to guide the programming of basic pH R in CRT patients.”
“Inflammatory abdominal aortic aneurysm (IAA) is associated with autoimmune disease. However, the precise mechanism of IAA remains unclear. There is increasing evidence that IgG4 is involved in the autoimmune mechanism of various idiopathic sclerosing lesions, including sclerosing pancreatitis and retroperitoneal fibrosis. The present study investigated the hypothesis that the IgG4-related autoimmune reaction is involved in the formation of IAA. The study group consisted of 11 cases of IAA (69.2 Ro-3306 +/- 8.59 y) and 12 age-matched cases of atherosclerotic abdominal aortic aneurysm

(AAA, 69.6 +/- 5.94y), which were used in the previous report. A clinicopathologic examination of these lesions was performed, including histology and immunohistochemistry, in relation to the involvement of IgG4-positive plasma cells in the formation of IAA. No difference in the incidence of risk factors for atherosclerosis was observed between the patients with IAA and AAA. Autoimmune diseases were diagnosed in 2 patients with IAA, including rheumatoid arthritis and polyarteritis nodosa. A patient with IAA had pulmonary fibrosis. In contrast, autoimmune diseases were absent in patients with AAA. However, there was no significant difference in the incidence of autoimmune diseases between the patients with IAA and AAA. Lymphocyte and plasma cell infiltration and fibrosis were significantly more intense and extensive in IAA than in AAA. In addition,

lymph follicle formation and vasculitis of small veins and arteries were frequently found in the affected lesions of IAA. Immunohistochemically, IAA showed a significant increase in the number of infiltrating IgG4-positive plasma cells and the incidence of a disrupted follicular dendritic cell network in lymph follicles, in comparison with AAA. These findings suggest that IAA may be an aortic lesion reflecting the presence of IgG4-related sclerosing disease, and not a simple inflammatory aneurysm of the Selleckchem P005091 aorta.”
“Argonaute proteins are the core components of the RNA-induced silencing complex, the central effector of the mammalian RNA interference pathway. In the cytoplasm, they associate with at least two types of cytoplasmic RNA granules; processing bodies and stress granules, which function in mRNA degradation and translational repression, respectively. The significance of Argonaute association with these RNA granules is not entirely clear but it is likely related to their activities within the RNAi pathway. Understanding what regulates targeting of Argonautes to RNA granules may provide clues as to their functions at these organelles.

Alcohol-dependence was find more also associated with persistent dACC and parahippocampal gyrus

activations in re-inclusion. PPI analyses showed reduced frontocingulate connectivity during social exclusion in alcohol-dependence. Alcohol-dependence is thus linked with increased activation in areas eliciting social exclusion feelings (dACC-insula), and with impaired ability to inhibit these feelings (indexed by reduced frontal activations). Altered frontal regulation thus appears implied in the interpersonal alterations observed in alcohol-dependence, which seem reinforced by impaired frontocingulate connectivity. This first exploration of the neural correlates of interpersonal problems in alcohol-dependence could initiate the development of a social neuroscience learn more of addictive states. Neuropsychopharmacology (2012) 37, 2067-2075; doi:10.1038/npp.2012.54; published online 18 April 2012″
“2-Demethoxy-2,3-ethylenediamino

hypocrellin B (EDAHB) is a diamino-substituted hypocrellin B (HB) with high absorption of red light and high quantum yield of both singlet oxygen (O-1(2)) and superoxide anions (O-2(center dot-)). Here we reported the cellular uptake, subcellular location, and cytotoxicity of EDAHB, as well as EDAHB-mediated photodynamic therapy (PDT) efficiency, and cell apoptosis. Results showed that EDAHB accumulated in HeLa cells rapidly up to 1 h, with a subsequent decrease in the rate of uptake. EDAHB distributed with well-defined spots throughout the cytoplasm of the cells. EDAHB showed a much higher photopotentiation factor than HB. The phototoxicity of EDAHB to HeLa cells occurred via a mitochondria/caspase apoptosis pathway. This study showed EDAHB to be a promising candidate of photosensitizer for anti-tumor PDT. (C) 2012 Elsevier B.V. All rights reserved.”
“Resistant starches (RS) play important roles in our nutrition; therefore, the investigation of these starches is notably important. In our study, two native starches (maize and wheat) and two resistant starches (Hi-maize (TM) 260,

high amylose maize starch as RS2 and Fibersym https://www.selleckchem.com/products/dmh1.html (TM) 70, phosphorylated wheat starch as RS4) were investigated as is and in their physical mixtures (samples containing 20%, 40%, 60% and 80% RS) using near-infrared (NIR) spectroscopy. The aim of our study was to examine the spectra of resistant starches and to differentiate the resistant starch components in different ratios by NIR spectroscopy. The differences of samples were presented in two characteristic absorption bands for carbohydrate: carbohydrate II (2,080-2,130 nm) and carbohydrate III (2,275-2,290 nm) regions. Additionally, principal component analysis (PCA) for all samples was carried out. It was shown that the increasing amount of amylose can be sensitively followed up in carbohydrate II region. The phosphorylated RS4 is not so characteristic probably due to the reduced mobility of amorphous chains; however, the RS4 addition can be observed.

The age

at disease diagnosis was lower in carriers of the ESR1 rs9340799 A allele compared with GG homozygotes as well as in patients with ESR1 rs2234693 TT and CT genotypes compared with CC homozygotes. There was no significant association of the genotypes with rheumatoid factor (RF), erosive disease, extra-articular manifestations, or anti-cyclic citrullinated peptide (anti-CCP) antibodies.\n\nConclusions: The results of the study suggest that polymorphisms in the ESR1 gene may be associated with the age of onset of RA.”
“Objective: To determine whether ovaries can be preserved in selected young women with peritoneal pseudomyxoma (PMP).\n\nBackground data: The traditional https://www.selleckchem.com/ATM.html rule is to systematically perform a bilateral oophorectomy.\n\nPatients and methods: A new policy was developed to preserve the ovaries when they are macroscopically normal in young women with PMP, strongly desiring a future pregnancy.\n\nResults: Thirty-three women younger than 41 years were

selected after undergoing complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for PMP. A normal ovary was preserved in 6 of them, but in see more 6 of the 14 women who strongly desired a future pregnancy. Subsequently, ovarian preservation was only performed in cases of grade-1 PMP. Ovarian invasion was correlated with the grade (p < 0.05) and with the extent of peritoneal disease (p < 0.01). After

a median follow-up of 54 months, none of the 6 women with preserved ovaries has developed an ovarian or a peritoneal recurrence. One woman became pregnant Metabolism inhibitor and egg harvesting and cryopreservation were performed for 4 women with a partially normal ovary.\n\nConclusion: This new policy allowed ovarian preservation in 43% of the young women desiring a future pregnancy and has already resulted in one birth. It exclusively concerned low-grade PMP. Recurrence in the preserved ovary was 0% with our selection criteria. (C) 2013 Elsevier Ltd. All rights reserved.”
“Background: The aim of the study was to identify the relationship between ‘Health Belief Model Scale for Cervical Cancer and the Pap Smear Test’ subscale scores and demographic/gyneco-obstetric characteristics. Materials and Methods: This cross-sectional study was conducted with 256 women. Data were obtained using the ‘Demographic and Gyneco-Obstetric Identification Form’ and the ‘Health Belief Model Scale for Cervical Cancer and the Pap Smear Test. Results: The percentage of women who had heard about the Pap test was 77.7 whereas only 32.4% had actually undergone the test. Some 45.7% of the women stated that they did not know the reason for having a Pap test. Women who had obtained a Pap smear test had statistically significantly fewer perceived barriers than those who had never had (p<0.05).

57%). Surgical

treatment ACY-738 price in the 57.14% was made with a good evolution in the 50%, whereas the patients with mild or moderate ischemic colitis had a better prognosis (favourable evolution in 80.95%) with smaller requirement of the surgical treatment (4.76%), p < 0.05.\n\nConclusion: the colitis ischemic are more frequent in the older age. The most frequent symptoms are the rectorrhagia and the abdominal pain. The colonoscopy is a useful technique to evaluate the gravity and it induces a change of attitude according to the result of the same one. The evidence of a serious colitis supposed an increase of the necessity of surgery and worse prognosis.”
“While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed a highly heterogeneous pattern globally characterized by regional DNA hypermethylation embedded in extensive hypomethylation. In contrast to the widely reported DNA hypermethylation of promoter-associated

CpG islands (CGIs) in cancer, hypermethylated sites in MM, as opposed to normal plasma cells, were located outside CpG islands and were unexpectedly associated with intronic enhancer regions defined in normal B cells and plasma cells. Both RNA-seq and in vitro reporter assays indicated that enhancer hypermethylation is globally associated with down-regulation of its host genes. ChIP-seq and DNase-seq further revealed that DNA hypermethylation in these regions is related to enhancer decommissioning. Hypermethylated enhancer regions overlapped with binding sites GDC-0973 mw of B cellspecific transcription factors (TFs) and the degree of enhancer methylation inversely correlated with expression levels of these TFs in MM. Furthermore, hypermethylated regions in MM were methylated in stem cells and gradually became demethylated during normal B-cell differentiation, suggesting that MM cells either reacquire epigenetic features of undifferentiated cells or maintain an epigenetic signature of a putative myeloma stem cell progenitor. Overall, we have identified DNA hypermethylation of developmentally regulated enhancers as a new type of epigenetic learn more modification

associated with the pathogenesis of MM.”
“Cassia auriculata (Caesalpiniaceae) is a common Asian beverage and medicinal plant widely used in tradition medicine for diabetes, hyperlipidemia and various other disease conditions. Previous studies on crude extracts of C. auriculata have documented the scientific basis for some of its traditional medicinal uses. The present study investigates the antilipase activity of the ethanol extract of the aerial parts along with the previously isolated compounds (kaempferol-3-O-rutinoside, rutin, kaempferol, quercetin and luteolin). The crude extract displayed inhibitory activity against pancreatic lipase with IC50 of 6.0 +/- 1.0 mu g/mL. The most active antilipase compound was kaempferol-3-O-rutinoside with IC50 value (2.9 +/- 0.

Our results showed that CS inhibited TNF-alpha-induced NF-kappa B activation and subsequent vascular Caspase inhibitor review cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“An inverse association between adult body mass index (BMI) and risk of endometriosis has frequently been reported. However, the association between body size during childhood and early adulthood and endometriosis is not as well documented.\n\nUsing data

collected from the Nurses’ Health Study II, a prospective cohort study of premenopausal US nurses, that began in 1989, we have attempted to clarify this relationship. Data are updated every 2 years with follow-up for these analyses through 2001. In 1989 women recalled their body size at ages 5, 10 and 20 years using a validated 9-level figure drawing.\n\nDuring 831 910 person-years

of follow-up, 1817 cases of self-reported laparoscopically-confirmed endometriosis were observed among women with no past infertility. After adjusting BX-795 clinical trial for age, birthweight, age at menarche, parity, oral contraceptive use and adult BMI, we observed a significant reduction in the incidence of endometriosis with increasing body size for all time periods. The relative risks (RRs) comparing the smallest and largest figure sizes to the middle category during childhood (ages 5-10) were 1.18 (95% confidence interval 1.02-1.36) and 0.82 (0.66-1.02), P-trend = 0.0002. At age 20, the RRs for the same comparisons were 1.32 (1.06-1.65) and 0.87 (0.74-1.03), P-trend = 0.04. Additional adjustment by menstrual cycle length and regularity yielded similar associations. The associations were stronger among nulliparous women than among parous women, although not all differences were statistically significant.\n\nIn this large cohort of premenopausal women, there was evidence of a persistent

inverse association between childhood and early adulthood body size and incidence of laparoscopically confirmed see more endometriosis, independent of adult BMI and menstrual cycle characteristics.”
“Since conventional techniques using periodontal probes have inherent drawbacks in the diagnosis of different grades of gingival inflammation, development of noninvasive screening devices becomes significant. Diffuse reflectance (DR) spectra recorded with white light illumination is utilized to detect periodontal inflammation from the oxygenated hemoglobin absorption ratio R620/R575. A multispectral imaging system is utilized to record narrow-band DR images at 575 and 620 nm from the anterior sextant of the gingivia of 15 healthy volunteers and 25 patients (N = 40).

With the introduction of the new European Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) system,

this number is likely to increase dramatically. The aim of this work was to test the acute toxicity of a number of anionic, cationic and non-ionic surfactants to embryos of the zebrafish (Danio rerio), over 48 hours, as a possible alternative to the standard 96-hour fish acute test. We measured the toxicities of 15 surfactants, and compared the results to previously generated adult D. rerio LC50 data (or other fish species, if these data were not available). Comparison of the LC50 data showed that embryos appear to be as sensitive to cationic RG-7388 mw and non-ionic surfactants as the adult fish, but possibly are more sensitive to anionic surfactants. Toxicity testing with the embryo test can be carried out more quickly than with the adult test, uses much less space and media, requires less effort, and therefore can be performed at a reduced cost. The embryo test may also uncover additional sub-lethal effects, although these were not

observed for surfactants. The data presented here show that the 48-hour embryo test can be considered as a suitable alternative to the adult acute fish test for surfactants.”
“This study proposes a bioprospection methodology regarding the antimicrobial potential of plant extracts against bacteria with cariogenic relevance. Sixty extracts were obtained from ten plants – (1) Jatropha weddelliana, (2) Attalea phalerata, (3) Buchenavia tomentosa, (4) Croton doctoris, (5) Mouriri elliptica, Selisistat Epigenetics inhibitor (6) Mascagnia benthamiana, (7) Senna aculeata, (8) Unonopsis guatterioides, (9) Allagoptera Screening Library chemical structure leucocalyx and (10) Bactris glaucescens – using different extraction methods -(A) 70 degrees ethanol 72 h/25 degrees C, (B) water 5 min/100 degrees C, (C) water 1 h/55 degrees C, (D) water 72 h/25 degrees C, (E) hexane 72 h/25 degrees C and (F) 90 degrees ethanol 72 h/25 degrees C. The plants were screened for antibacterial activity at 50 mg/ml using the agar well diffusion test against Actinomyces naeslundii

ATCC 19039, Lacto-bacillus acidophilus ATCC 4356, Streptococcus gordonii ATCC 10558, Streptococcus mutans ATCC 35688, Streptococcus sanguinis ATCC 10556, Streptococcus sobrinus ATCC 33478 and Streptococcus mitis ATCC 9811. The active extracts were tested to determine their minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), cytotoxicity and chemical characterization. Forty-seven extracts (78%) were active against at least one microorganism. Extract 4A demonstrated the lowest MIC and MBC for all micro-organisms except S. gordonii and the extract at MIC concentration was non-cytotoxic. The concentrated extracts were slightly cytotoxic. Electrospray ionization with tandem mass spectrometry analyses demonstrated that the extract constituents coincided with the mass of the terpenoids and phenolics. Overall, the best results were obtained for extraction methods A, B and C.

Methods: 95 patients were followed-up for 24-60 months. Serial CTO measurements were performed every 3-6 months and correlated to clinical symptoms, lung function (FVC and DLco) and chest X-ray. In 38 patients clinical outcome status (COS) at 5 years was determined. Results: Initial CTO levels were significantly higher in patients with impaired FVC/DLco (p = 0.011 for both) but there was no correlation with standard chest X-ray stages. Patients with Loefgren’s syndrome had significantly lower initial and control CTO level compared to other patients (p = 0.011 and p = 0.001, respectively). At follow-up there was a positive correlation of CTO and deterioration of clinical symptoms (p smaller than 0.001), chest X-ray

Autophagy assay (p smaller than 0.001) and FVC/DLco (p = 0.012 and p = 0.086, respectively). Control CTO levels were significantly lower in no disease groups versus minimal or persistent disease NU7441 purchase group as defined by COS (p = 0.003 and p smaller than 0.001, respectively). At relapse CTO increased for 100% or more from baseline value in 12/14 patients. Conclusions: It was shown that CTO correlates with certain sarcoidosis phenotypes (Loefgren’s syndrome, COS) and that serial measurements of CTO correlate with clinical symptoms, chest radiographs and lung function.

(C) 2014 Elsevier Ltd. All rights reserved.”
“It is known that initial loading curves of soft biological tissues are substantially different from subsequent loadings. The later loading curves are

generally used for assessing the mechanical properties of a tissue, and the first loading cycles, referred to as preconditioning, are omitted. However, slow viscoelastic phenomena related to fluid DZNeP flow or collagen viscoelasticity are initiated during these first preconditioning loading cycles and may persist during the actual data collection. When these data are subsequently used for fitting of material properties, the viscoelastic phenomena that occurred during the initial cycles are not accounted for. The aim of the present study is to explore whether the above phenomena are significant for articular cartilage, by evaluating the effect of such time-dependent phenomena by means of computational modeling. Results show that under indentation, collagen viscoelasticity dominates the time-dependent behavior. Under UC, fluid-dependent effects are more important. Interestingly, viscoelastic and poroelastic effects may act in opposite directions and may cancel each other out in a stress-strain curve. Therefore, equilibrium may be apparent in a stress-strain relationship, even though internally the tissue is not in equilibrium. Also, the time-dependent effects of viscoelasticity and poroelasticity may reinforce each other, resulting in a sustained effect that lasts longer than suggested by their individual effects. Finally, the results illustrate that data collected from a mechanical test may depend on the preconditioning protocol.

\n\nResults: In this study, four epitopes from OmpL1 and four from LipL41 conserved regions were evaluated for their potential utilization in leptospire vaccines. Firstly,

combined B and T cell epitopes were predicted by softwares and expressed using a phage display system. OmpL1 residues 87-98 and 173-191 (OmpL1(87-98) and OmpL1(173-191)) and LipL41(30-48), LipL41(233-256) of LipL41 were identified as immunodominant B cell epitopes by Western blot. Epitopes OmpL1(173-191), OmpL1(297-320) of OmpL1 and LipL41(233-256), LipL41(263-282) of LipL41 were identified as immunodominant CD4(+) T cell epitopes through proliferation analysis of splenocytes from recombinant OmpL1 (rOmpL1) or recombinant LipL41 (rLipL41)-immunized BALB/c (H-2(d)) mice. These epitopes induced responses of CD4(+) T cells and Th1 (T helper cells) Fosbretabulin molecular weight type cytokine responses during the infection.\n\nConclusion: This work identified combined T and B cell immunodominant epitopes in outer membrane proteins OmpL1 and LipL41 of Leptospira interrogans. OmpL1(173-191) of OmpL1 and LipL41(233-256) of LipL41 could be useful in a vaccine against Leptospira. The findings could also contribute to the development of effective cross-protective vaccine strategies for leptospirosis.”
“The response of free nitrous acid (FNA)-adapted

poly-phosphate accumulating organisms (PAOs) to FNA inhibition under aerobic and anoxic conditions was studied. FDA approved Drug Library screening Anoxic P-uptake was 1-6 times more sensitive to the inhibition compared to aerobic P-uptake. The aerobic nitrite reduction rate increased with FNA concentration, accompanied by an equivalent decrease in the oxygen uptake see more rate, suggesting under high FNA concentration conditions, electrons were channeled to nitrite reduction from oxygen reduction. In contrast, the nitrite reduction

rate decreased with increased FNA concentration under anoxic conditions. Anaerobic metabolism of PAO under both anoxic and aerobic conditions was observed at high FNA concentrations. Growth of PAOs decreased sharply with FNA concentration and stopped completely at FNA concentration of 10 mu g HNO2-N/L. This study, for the first time, investigated the function of nitrite/FNA in an aerobic denitrifying phosphate removal process by evaluating electron as well as energy balances, and provides explanation for FNA inhibition mechanisms. (C) 2012 Elsevier Ltd. All rights reserved.”
“Patients with chronic liver disease have an increased risk of developing transfusion-related acute lung injury (TRALI) from plasma-containing blood products. Similarly, red blood cell transfusions have been associated with postoperative and nosocomial infections in surgical and critical care populations.

0 +/- 1.5; P<.001) and improved shoulder function (force production, 2.5 +/- 1.4 kg; Penn Shoulder Score, 7.7 +/- 9.4; sports/performing arts module of the Disabilities of the Arm, Shoulder and Hand questionnaire, 16.4 +/- 13.2) (all, P<.001).\n\nCONCLUSION: Immediate improvements in shoulder pain and function post-TSM are not likely explained by alterations in scapular kinematics or shoulder muscle activity. For people with pain associated with RCT, TSM may be an effective component of their treatment plan to improve pain and function. However, further randomized controlled studies are necessary to better validate this treatment approach.”
“HIV transmission

is a major health concern. Global efforts are necessary to control SHP099 order the spread of infection. International collaborative studies in countries with high rates of new infections are essential

for increasing knowledge on the behavioral, social, and biomedical aspects of HIV/AIDS and HIV transmission. Statistics indicate a growing HIV epidemic in Russia. There are alarming proportions of new cases attributed to heterosexual contact, and HIV is increasingly affecting people in the general population who are not part of any traditional high-risk group. Despite recent advances in HIV prevention, data on effective behavioral prevention approaches are limited. There is minimal evidence to suggest which types of prevention will be effective in reducing the risk for HIV transmission

among people at risk in the general population. This article learn more presents a review and discussion of an international research seminar, HIV Prevention Research: Evidence-Based Behavioral Approaches. Local PF-03084014 chemical structure and international interdisciplinary researchers gathered for the purposes of exchanging research results and information about ongoing studies, identifying gaps in knowledge, and discussing promising prevention strategies. The overarching goal was to advance HIV prevention research through scientific integration. The seminar provided an excellent platform for building research capacity in interdisciplinary HIV research in Russia and integrating research efforts with the international research community to contribute to HIV prevention research throughout the world.”
“Current therapeutic options for acute kidney injury (AKI) are limited to the use of supportive measures and dialysis. A recent approach that has sparked great interest and gained enormous popularity is the implantation of stem cells to repair acutely damaged kidney organ. Hypoxia inducible factor-1 alpha (HIF-1 alpha) is effective in protecting the kidney from ischemia and nephrotoxicity. In this study, we investigated whether HIF-1 alpha-modified adipose-derived stem cells (ASCs) had an enhanced protective effect on cisplatin-induced kidney injury in vivo. Cisplatin-induced AKI was established in nude mice.