coli genetic backgrounds, indicating a proteolysis targeting role for DnaK. However, solubility is highly compromised in a DnaK- E. coli strain suggesting an important role of this chaperone in reduction of protein aggregates. Finally, hemagglutination efficiency of recombinant VP1 is directly related to the presence of DnaK in the producing cells. (c) 2014 American Institute of Chemical Engineers Biotechnol. Prog.,

30:744-748, 2014″
“Rats fed a high-fat diet (HFD) present an exaggerated endocrine response to stress conditions, which, like obesity, show a high correlation with cardiovascular diseases. www.selleckchem.com/products/ink128.html Meanwhile the GABAergic neurotransmission within the dorsomedial hypothalamus (DMH) is involved in the regulation of the physiological responses during emotional stress. Here we evaluated

the influence of obesity, induced by a HFD, on the cardiovascular responses induced by air jet stress in rats, and the role of the GABAergic tonus within the DMH in these changes. Our results showed that consumption of a HFD (45% w/w fat) for 9 weeks induced obesity and increases in baseline mean arterial pressure (MAP) and heart rate (HR). Moreover, obesity potentiated stress responsiveness, evidenced by the greater changes in MAP and HR induced by stress in obese rats. The injection of muscimol into JNK inhibitor concentration the DMH reduced the maximal increases in HR and MAP induced by stress in both groups; however, the reduction in the maximal increases in MAP in the DMXAA clinical trial HFD group was less pronounced.

Moreover, the injection of muscimol into the DMH of obese rats was less effective in reducing the stress-induced tachycardia, since the HR attained the same levels at the end of the stress paradigm as after the vehicle injection. Injection of bicuculline into DMH induced increases in MAP and HR in both groups. Nevertheless, obesity shortened the tachycardic response to bicuculline injection. These data show that obesity potentiates the cardiovascular response to stress in rats due to an inefficient GABA(A)-mediated inhibition within the DMH. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Purpose: Ovarian cancer, like most solid tumors, is in dire need of effective therapies. The significance of this trial lies in its promise to spearhead the development of combination immunotherapy and to introduce novel approaches to therapeutic immunomodulation, which could enable otherwise ineffective vaccines to achieve clinical efficacy.\n\nRationale: Tumor-infiltrating T cells have been associated with improved outcome in ovarian cancer, suggesting that activation of antitumor immunity will improve survival. However, molecularly defined vaccines have been generally disappointing. Cancer vaccines elicit a modest frequency of low-to-moderate avidity tumor-specific T-cells, but powerful tumor barriers dampen the engraftment, expansion and function of these effector T-cells in the tumor, thus preventing them from reaching their full therapeutic potential.

“
“Sweet orange [Citrus sinensis (L.) Osbeck] represents the most important Citrus species, followed by clementine (C. clementina click here Hort. ex Tan.). Citrus species and genotypes are difficult to recognize as they have a moderate level of diversity due to nucellar selection, vegetative propagation and origin by single spontaneous mutation. Despite the large number of available sequences and the existence of a draft assembly of sweet orange and clementine, there are currently no single nucleotide polymorphism (SNP) databases for Citrus species. For this purpose, the QualitySNP software was used to discover SNPs in 19 Citrus species starting from 540,000 expressed sequence

tags (ESTs) assembled in 52,000 contigs. The vast majority of ESTs, contigs and SNPs were found in C. clementina and C. sinensis: 4,400 out of 16,000 contigs (27 %) of C. clementina and 4,100 out of 17,000 contigs (24 %) of C. sinensis contained putative SNPs. A total of 3,634 sequences were associated see more with enzymes

belonging to 121 metabolic KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, among which the secondary metabolite pathway was the most represented. A total of 163 SNPs from 52 contigs and genes of specific functional categories were validated and 81 polymorphic sites were found. Thirty-seven selected SNPs, validated by Sanger sequencing, confirmed that polymorphisms were mainly between species, while poor within-species variability Caspase-8 Inhibitor was discovered. This work provides a collection of 15,879 putative SNP markers that could be exploited by the Citrus community. Furthermore, the validated SNPs associated with specific genes could be used for functional genetic studies in germplasm diversity analysis, mapping and breeding.”
“The Xpert MTB/RIF assay is a rapid and fully automated real-time PCR assay. The performance of the Xpert MTB/RIF assay as a primary screening test for urgent clinical specimens was evaluated during a 2-year period. The results showed that replacing smear microscopy with the Xpert MTB/RIF assay facilitates laboratory handling

and improves the sensitivity and specificity of Mycobacterium tuberculosis detection.”
“The extraction of accurate self-motion information from the visual world is a difficult problem that has been solved very efficiently by biological organisms utilizing non-linear processing. Previous bio-inspired models for motion detection based on a correlation mechanism have been dogged by issues that arise from their sensitivity to undesired properties of the image, such as contrast, which vary widely between images. Here we present a model with multiple levels of non-linear dynamic adaptive components based directly on the known or suspected responses of neurons within the visual motion pathway of the fly brain.

The probability of faecal contamination of milk, and thus the risk of pathogens transfer appears to be modulated more by farm management than by the structure of the farm or the health status

of the herd. Such a method, combined with the microbiological evaluation of the prevalence of faecal excretion of such pathogens, can be used to implement a risk-based surveillance programme and to apply targeted control measures. (c) 2013 Elsevier Ltd. All rights reserved.”
“Cardanol-based novolac resins were separately prepared with different mole ratios of cardanol-to-formaldehyde with different acid catalysts. These resins were epoxidized with epichlorohydrin, in basic medium, at 120 degrees C. The resins were, separately, blended with different weight percentages of carboxyl-terminated butadiene acrylonotrile copolymer and cured with polyamine. Structural Dibutyryl-cAMP changes during blending were studied by FTIR spectroscopic analysis. Coats-Redfern equation was utilized to calculate the kinetic parameters, viz., order of decomposition reaction (n), activation energy (E), pre-exponential factor (Z), and rate decomposition constant (k), for the decomposition of the samples. It was found that the degradation GSK1120212 of the epoxies and their blend samples proceeded in two steps. (C) 2009 Wiley

Periodicals, Inc. J Appl Polym Sci 114:1694-1701, 2009″
“Aim. Extrapulmonary tuberculosis treatment is P005091 in vitro difficult to assess and there is a need for new tools. The aim of this observational pilot study is to evaluate the potential

role of 18F-FDG PET/CT in the initial staging and treatment evaluation of extrapulmonary tuberculosis.\n\nMethods. Twenty-eight patients were included between January 2009 and 2010. Twenty-three had a 18F-FDG PET/CT before treatment and/or during and/or after treatment. All patients will be followed for 18 months after the end of treatment. A control group of five patients with previous history of tuberculosis was also included and PET/CT was performed.\n\nResults. Three cases of differential diagnosis were excluded of the study. The initial PET for staging showed additional lesions in 8/10 patients compared to conventional imaging. At the end of treatment, 6/11 patients had a negative PET, and 5/11 patients had a positive PET. PET had a significant clinical impact for 3/10 patients at initial staging (guiding biopsy or increase of planned treatment duration), and for 3/16 during follow up (extend or early interruption of the treatment). All PET scans in the control group were negative.\n\nConclusion. 18F-FDG PET has an excellent sensitivity for the detection of extrapulmonary tuberculosis lesion and excellent negative predictive values. The impact of initial PET staging seems significant.

This article describes the clinical characteristics of FL, its prognostic indicators, and its clinical course, including transformation to an aggressive selleckchem lymphoma. Primary management and therapies for recurrent FL are detailed.”
“Increasing evidences suggest that the type I interferon alpha (IFN alpha) plays a critical role in the etiopathogenesis of systemic lupus erythematosus (SLE), which makes it a promising therapeutic target for the treatment of the disease. By screening a large size non-immune human antibody library,

we have developed a human single-chain antibody (ScFv) AIFN alpha 1bScFv01 and corresponding whole antibody AIFN alpha 1bIgG01 to human interferon alpha 1b (IFN alpha 1b) with high specificity and high affinity. The IgG antibody could down-regulate

the expression of ISG15 and IFIT-1 induced by either recombinant IFN alpha 1b or na < ve IFN Dinaciclib molecular weight alpha from SLE patients’ sera, and reduced total serum IgG and IgM antibodies level in a pristane-primed lupus-like mouse model. The crystal structure of AIFN alpha 1bScFv01-IFN alpha 1b complex solved to 2.8 resolution revealed that both Pro26-Gln40 region in loop AB and Glu147-Arg150 region in helix E of IFN alpha 1b contribute to binding with AIFN alpha 1bScFv01. Four residues of above two regions (Leu30, Asp32, Asp35 and Arg150) are critical for the formation of antigen-antibody complexes. AIFN alpha 1bScFv01 shares partial selleck chemicals llc epitopes of IFN alpha 1b with its receptor IFNAR2 but with much higher binding affinity to IFN alpha 1b than IFNAR2. Thus, AIFN alpha 1bIgG01 exhibits its neutralizing activity through competition with IFNAR2 to bind with IFN alpha and prevents the activation of IFN alpha-mediated signaling pathway. Our

results highlight the potential use of the human antibody for modulating the activity of IFN alpha in SLE.”
“The objective of this case report is to describe the laparoscopic insertion of an artificial periprostatic urinary sphincter. We report the case of a paraplegic patient in whom an artificial urinary sphincter was inserted in a periprostatic position by way of laparoscopy to treat stress urinary incontinence. In addition to laparoscopy being minimally invasive, its advantages include the excellent quality of retroprostatic dissection and the perfect visualization it gives at the level of cuff positioning with respect to the anatomic landmarks. It is more appropriate to be able to cleave the interprostatorectal space to ensure passage of the cuff under perfectly safe conditions. UROLOGY 73: 442.e1-442.e3, 2009. (C) 2009 Elsevier Inc.”
“Purpose: Achieving the desired outcome in rhinoplasty depends on many factors. Osteotomy and adjustment of the lateral nasal wall are important steps that necessitate careful planning and execution.

Unexpectedly, modification with a Ga-DOTA complex can have tremendous effects on the uptake efficiency. The results of these studies support the need of detailed analysis of each carrier peptide/cargo construct, especially in the field of metal complex modified CPR. (C) 2009 Wiley Periodicals, Inc. Biapolymers (Pept Sci) 92: 445-451, 2009.”
“Invadopodia-dependent degradation of the basement membrane plays a major role during metastasis

of breast cancer cells. Basement membrane degradation is mediated by targeted secretion of various matrix metalloproteinases (MMPs). Specifically, MMP2 and MMP9 (MMP2/9) possess the ability to hydrolyze components of the basement membrane and regulate various aspects of tumor growth and metastasis. However, the membrane transport machinery that mediates targeting of MMP2/9 to the invadopodia during cancer cell invasion remains to be defined. Because Rab GTPases are selleck screening library GW4869 cost key regulators of membrane transport, we screened a human Rab siRNA library and identified Rab40b GTPase as a protein required for secretion of MMP2/9. We also have shown that Rab40b functions during at least two distinct steps of MMP2/9 transport. Here, we demonstrate that Rab40b is required for MMP2/9 sorting into VAMP4-containing secretory vesicles. We also show that Rab40b regulates transport of MMP2/9 secretory vesicles during invadopodia formation and is required for invadopodia-dependent

extracellular matrix degradation. Finally, we demonstrate that Rab40b is also required for breast cancer cell invasion in vitro. On the basis of these findings, we propose that Rab40b mediates trafficking of MMP2/9 during invadopodia formation and metastasis of breast cancer cells.”
“Nitric oxide (NO) is a marker of pulmonary inflammation. https://www.selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html In asthma, the levels of exhaled NO are elevated and the source of this increased NO is inducible nitric oxide synthase (iNOS) within airway epithelial cells. Epimagnolin and fargesin are compounds isolated from the ethanol extract of Magnoliae flos, the seed of the Magnolia plant and are used

to treat nasal congestion, headache and sinusitis in Asian countries. This study investigated whether epimagnolin and fargesin inhibit extracellular signal-regulated kinase (ERK) activation and decrease iNOS expression and NO production in stimulated human respiratory epithelial cells. An immortal Type II alveolar cell line of human origin (A549) was stimulated by cytomix (CM), composed of IL-1 beta, TNF-alpha and IFN-gamma, with or without concurrent exposure to M.flos extract (epimagnolin or fargesin). CM-induced levels of NO production, iNOS expression and ERK activation were evaluated. A549 cells stimulated with CM showed increases in iNOS mRNA and protein expression, and NO synthesis. However, treatment with epimagnolin or fargesin decreased levels of iNOS mRNA and protein expression, and NO synthesis.

001) in fascicle length during the torque-matching tasks and change in torque fluctuation (CV) was positively associated with changes in fascicle length (r(2) = 0.56; P < 0.001), MG and TA EMG activities, and coactivation (r(2) = 0.35, 0.34, and 0.35, respectively; P < 0.001). In conclusion, these observations indicate that repeated stretches can decrease torque steadiness by

increasing muscle compliance and EMG activity of muscles around the joint. The relative influence of such adaptations, however, may depend on the torque level during the torque-matching task.”
“Objective To initiate a long-term care facility (LTCF) infectious disease (LID) service that provides on-site consultations to LTCF residents to improve

the care of residents with possible infections. Design Clinical demonstration project. Setting A 160-bed LTCF Akt inhibitor affiliated with a tertiary care Veterans Affairs (VA) hospital. Participants Residents referred to the LID team. Measurements The reason for and source of LTCF residents’ referral to the LID team and Z-VAD-FMK concentration their demographic characteristics, infectious disease diagnoses, interventions, and hospitalizations were determined. Results Between July 2009 and December 2010, the LID consultation service provided 291 consultations for 250 LTCF residents. Referrals came from LTCF staff (75%) or the VA hospital’s ID consult service (25%). The most common diagnoses were Clostridium difficile infection (14%), asymptomatic bacteriuria (10%), and urinary tract infection

(10%). More than half of referred residents were receiving antibiotic therapy when they first saw the LID team; 46% of residents required an intervention. The most common interventions, stopping (32%) or starting (26%) antibiotics, were made in accordance with principles of antibiotic stewardship. Conclusion The LID team represents a novel and effective means to bring subspecialty care to LTCF residents.”
“Objectives-The pretransverse or first segment of the vertebral artery maybe confused with adjacent branches of the proximal subclavian GSK923295 manufacturer artery during Doppler assessment. This study investigated the effectiveness of mastoid process percussion, the “mastoid tap” maneuver, for identification of the vertebral artery ostium.\n\nMethods-Fifty patients presenting consecutively for carotid sonography were recruited. Doppler waveforms were collected at the vertebral artery ostia, thyrocervical trunks, and proximal subclavian arteries while the mastoid tap maneuver was performed. The outcome indicator was serrate distortion of the Doppler waveform. Two raters graded the waveforms according to a 3-grade system: grade 0, no distortion; grade 1, mild distortion; and grade 3, marked distortion. The difference between the proportions of the vertebral artery ostia and thyrocervical trunks showing waveform distortion was evaluated with the chi(2) test.

The strain grew at 10-40 degrees C (optimum at 30 degrees C) and with 0-12% (w/v, optimum 2%) NaCl. It reduced nitrate to nitrite but learn more did not hydrolyse gelatin, starch or Tween 80. Analysis of 16S rRNA gene sequences showed that strain P-50-3(T) clustered tightly

with the genus Albimonas and shared the highest 16S rRNA gene sequence similarity (94.3 %) with the type strain of Albimonas donghaensis. The major respiratory quinone was Q-10 and the major cellular fatty acids were C-18:1 omega 7c, C-18:0, 11-methyl C-18:1 omega 7c and C-16:0 Polar lipids included phosphatidylglycerol (PG), phosphatidylcholine (PC), two unidentified aminolipids and an unidentified lipid. The genomic DNA G+C content of strain P-50-3(T) was 69.0 mol%. Proteasome inhibitors in cancer therapy On the basis of the data obtained in this polyphasic study, strain P-50-3(T) represents a novel species within the genus Albimonas, for which the name Albimonas pacifica sp. nov. is proposed. The type strain of Albimonas pacifica is P-50-3(T) (=KACC 16527(T)=CGMCC

1.11030(T)). An emended description of the genus Albimonas Lim et al. 2008 is also proposed.”
“Purpose: To characterize the aerial parts of Andrographis paniculata, a bitter Indian herb grown in Nigeria, for the purpose of quality control.\n\nMethods: The determination of bitterness value and of various physicochemical characteristics; tests for key phytochemicals; and thin layer chromatography (TLC) of the air-dried herb, were carried out as prescribed in standard texts.\n\nResults: The mean bitterness value of the herb for both men and women was 2.86 +/- 1.74 x 10(3) units per g. The male

value (2.07 +/- 1.42 x 10(3)) appeared to be lower than the female’s (3.52 +/- 1.82 x 10(3)) but the difference was not statistically significant. The results (% w/w) of loss on drying (10.64 +/- 0.36), total ash (14.10 +/- 4.49), water extractive value (30.37 +/- 2.63) and acid insoluble ash (1.00 +/- 0.06) were similar to those reported for the Asian plant. The phytochemical tests revealed the presence of glycosides, saponins, XMU-MP-1 solubility dmso tannins and alkaloids, but not of anthraquinones. Normal phase TLC of the drug yielded 5 spots as against 6 spots yielded by reverse TLC.\n\nConclusion: The results provide useful quantitative and descriptive data that are essential for identifying and characterizing the Nigerian grown herb for the purpose of quality control; and confirm key similarities between the Nigerian and the Asian plant.”
“The beta-carboline alkaloids of Peganum harmala L were extracted through a bioassay-guided fractionation and their antimicrobial activities were investigated. Results revealed significant differences (P>0.05) between compounds depending on the microorganism tested and the application method. When examined individually, harmine was the most effective against Proteus vulgaris, Bacillus subtilis and Candida albicans where inhibition zones ranged between 21.2 and 24.7 mm.

Each Barasertib inhibitor photoperiod group was formed with five replicates at two different stocking densities (normal stocking density: 12 broiler/m(2), high stocking density: 20 broiler/m2). The experiment was carried for 42 days. At the end of the experiment, the effect of photoperiod and stocking density on live weight gain were significant (P smaller than 0.05) while photoperiod significantly affected the feed consumption only (P smaller than 0.05). The feed efficiency were insignificant (P bigger than 0.05) with respect to both factors. The photoperiod programs had

significant effects on the relative weight of gizzard, blood, feather percentage values (P smaller than 0.05) and breast percentage values (P smaller than 0.01). The stocking density has a significant effect on relative heart weight (P smaller than 0.05) and entire thigh values (P smaller

than 0.01). At the end of the experiment, it was ascertained that the photoperiod program and stocking density had no significant (P bigger than 0.05) difference on tonic immobility and tibial dyschondroplasia values. However, stocking density had a highly significant effect (P smaller than 0.01) on gait score values and on heterophil-lymphocyte rate values (P smaller than 0.01).”
“Long intercalated defects in canine ribs can be repaired successfully using porous beta-tricalcium phosphate (beta-TCP) cylinders, infused with a biodegradable

polymer 3-Methyladenine supplier (Poly D,L-lactic acid-polyethylene block copolymer) containing recombinant human bone morphogenetic protein-2 (rhBMP-2). We previously reported the successful regeneration of bony rib and periosteum defects using beta-TCP cylinders containing 400 mu g of rhBMP-2. To reduce the amount of rhBMP-2 and decrease the time required for defect Napabucasin manufacturer repair, we utilized a biodegradable polymer carrier, in combination with rhBMP-2 and the porous beta-TCP cylinders. An 8 cm long section of rib bone was removed and replaced with an implant comprised of the porous beta-TCP cylinders and the polymer containing 80 mu g of rhBMP-2. Six weeks after surgical placement of the beta-TCP cylinder/polyrner/BMP-2 implants, new rib bone with an anatomical configuration and mechanical strength similar to the original bone was regenerated at the defect site. The stiffness of the regenerated ribs at 3, 6, and 12 weeks after implantation of the composite implant was significantly higher than that of ribs regenerated by implantation of rhBMP-2/beta-TCP implants. Thus, addition of the synthetic polymer to the drug delivery system for BMP potentiated the bone-regenerating ability of the implant and enabled the formation of mechanically competent rib bone. This new method appears to be applicable to the repair of intercalated long bone defects often encountered in clinical practice.

This stimulates a cascade of events, including activation of insulin-like growth factor I receptor (IGF-IR), phosphatidylinositol 3-kinase-mediated phosphorylation of AKT, inhibition of GSK-3 beta, increased activation of beta-catenin, and associated lymphoid-enhancing factor/T cell factor-mediated transcription. Initiation of this pathway does not involve the Wnt/LRP5/Frizzled receptor and does not culminate in increased IGF transcription. The effect of strain on IGF-IR is mimicked by exogenous des-(1-3)IGF-I and

is blocked by the IGF-IR inhibitor H1356. Inhibition of strain-related prostanoid and nitric NU7441 manufacturer oxide production inhibits strain-related (and basal) AKT activity, but their separate ectopic administration does not mimic it. Strain-related IGF-IR activation GSK2126458 of AKT requires estrogen receptor

alpha (ER alpha) with which IGF-1R physically associates. The ER blocker ICI 182,780 increases the concentration of des-(1-3) IGF-I necessary to activate this cascade, whereas estrogen inhibits both basal AKT activity and its activation by des-(1-3) IGF-I. These data suggest an initial cascade of strain-related events in osteoblasts in which strain activates IGF-IR, in association with ER alpha, so initiating phosphatidylinositol 3-kinase/AKT-dependent activation of beta-catenin and altered lymphoid-enhancing factor/T cell factor transcription. This cascade requires prostanoid/nitric oxide production and is independent of

Wnt/LRP5.”
“In this conference paper, we show that estrogen receptor-beta status influences clinical outcome of triple-negative breast cancer referring two of our recent research articles.”
“As in all parts of the globe, rapid climate change in Australia PFTα concentration will have significant negative impacts on biodiversity. It also will interact with pre-existing stressors such as native vegetation clearing, altered natural disturbance regimes and invasive species – all of which already have major negative effects on biota in Australia. Strategies to reduce climate change impacts on Australian biodiversity include a mixture of mitigation and adaptation actions (sensu Millar et al., 2007) such as: (1) significantly reducing greenhouse gas emissions, (2) ensuring bio-diverse carbon capture, (3) better tackling pre-existing stressors on biodiversity, (4) better preparing for the effects of major natural disturbances, (5) significantly improving off-reserve conservation efforts including fostering appropriate connectivity, and (6) enhancing the existing reserve system by making it more comprehensive, adequate and representative. The first strategy above demands a global response otherwise major mitigation attempts in Australia that are not paralleled elsewhere around the world will have little effect on climate change and, in turn, contribute little to enhanced biodiversity conservation.

“
“Objective Crohn’s disease is a chronic inflammatory process that has recently been associated with a higher risk of early implant failure. Herein we provide information AZD7762 on the impact of colitis on peri-implant bone formation using preclinical models of chemically induced colitis. Methods Colitis was induced by intrarectal instillation of 2,4,6-trinitro-benzene-sulfonic-acid (TNBS).

Colitis was also induced by feeding rats dextran-sodium-sulfate (DSS) in drinking water. One week after disease induction, titanium miniscrews were inserted into the tibia. Four weeks after implantation, peri-implant bone volume per tissue volume (BV/TV) and bone-to-implant contacts (BIC) were determined by histomorphometric analysis. Results Cortical histomorphometric parameters were similar in the control (n = 10), DSS (n = 10) and TNBS (n = 8) groups. Cortical SB203580 chemical structure BV/TV was 92.2 +/- 3.7%, 92.0 +/- 3.0% and 92.6 +/- 2.7%. Cortical BIC was 81.3 +/- 8.8%, 83.2

+/- 8.4% and 84.0 +/- 7.0%, respectively. No significant differences were observed when comparing the medullary BV/TV and BIC (19.5 +/- 6.4%, 16.2 +/- 5.6% and 15.4 +/- 9.0%) and (48.8 +/- 12.9%, 49.2 +/- 6.2 and 41.9 +/- 11.7%), respectively. Successful induction of colitis was confirmed by loss of body weight and colon morphology. Conclusions The results suggest bone regeneration around implants is not impaired in chemically induced colitis models. Considering that Crohn’s disease can affect any part of the gastrointestinal tract including the mouth, our model only partially reflects Selleck PD-1/PD-L1 Inhibitor 3 the clinical situation.”
“Aqaba is one of the most strategic cities in Jordan and the entire region, as it is the only seaport for Jordan and has a special economic zone as the only window to global markets. The main purpose of this study is to detect urban development in Aqaba region by detecting and registering

linear features in images with various geometric and radiometric properties taken at different times. This article used linear features for image registration that were chosen since they can be reliably extracted from imagery with significantly different geometric and radiometric properties. The modified iterated Hough transform (MIHT) is used as the matching strategy for automatically deriving an estimate of the parameters involved in the transformation function relating the images to be registered as well as the correspondence between conjugate lines. Derived edges from the registered images are used as the basis for change detection. The utilization of edges is motivated by the fact that they are invariant with respect to possible radiometric differences between the images in question. Linear features extraction, feature matching, image registration and pixel-pixel subtraction have been implemented using SPOT, Landsat, Ikonos and aerial photographs that have different radiometric, spatial and temporal resolutions.