Indoxyl sulfate level at baseline were 3.05 ± 1.10 and 2.17 ± 0.91 mg/dl in pre- and post-dialysis sessions respectively while
it returned to the previous level before the next dialysis sessions. However, AST-120 significantly decreased the levels of indoxyl sulfate in both pre- (1.70 ± 0.75 mg/dl, P = 0.006 vs. baseline) dialysis treatment. Conclusion: Use of AST-120 showed a continuous and powerful effect to remove protein-bound uremic toxins in maintenance hemodialysis patients. AMARI YOSHIFUMI1,2, MORIMOTO SATOSHI1, RYUZAKI MASAKI1, ANDO TAKASHI1, OKAMOTO TAKAYUKI1,2, WATANABE DAISUKE1, MORI NORIKO1, IIDA TAKESHI2, YURUGI TAKATOMI2, NAKAJIMA FUMITAKA2, ICHIHARA ATSUHIRO1 1Department of Medicine II, Endocrinology and Hypertension, Tokyo Women’s Medical University, Tokyo, Japan; 2Moriguchi click here Keijinkai Hospital, Moriguchi, Japan Introduction: The (pro)renin receptor [(P)RR] is expressed in several tissues including kidneys and plays an
important role in regulating selleck the tissue renin-angiotensin system (RAS) through the non-proteolytic activation of prorenin, the precursor of renin. (Pro)renin receptor is cleaved by furin to generate soluble(P)RR [s(P)RR], which is secreted into the extracellular space. It is supposed that serum s(P)RR level can relate to the tissue RAS and can be a biomarker reflecting the status of the tissue RAS. Hemodialysis patients have poor prognosis due to increased prevalence of cardiovascular diseases. Although it is possible that activation of the tissue RAS by (P)RR is associated with this condition, Bacterial neuraminidase it remains speculative. The present study thus aimed to determine serum s(P)RR levels in hemodialysis patients and to assess the relationship between serum s(P)RR levels
and background factors. Methods: Serum s(P)RR levels were measured in 258 maintenance hemodialysis patients and these values were compared with 25 subjects with normal renal function. In addition, clearance of s(P)RR through one hemodialysis therapy was examined. Furthermore, relationship between serum s(P)RR levels and background factors were assessed in maintenance hemodialysis patients. Results: Serum s(P)RR levels in maintenance hemodialysis patients were 30.4 ± 6.1 ng/ml and were significantly higher than those in subjects with normal renal function (16.5 ± 4.3 ng/ml, P < 0.0001). Serum (P)RR levels were significantly higher in those with ankle-brachial index (ABI) of <0.9, an indicator of severe stenosis or obstruction of lower limb arteries, than those of ≧0.9 (32.2 ± 5.9 and 30.1 ± 6.2 ng/ml, respectively; P < 0.05). The association between low ABI and high serum s(P)RR levels were observed even after adjusting for age, history of smoking, HbA1c, and LDL-C. Conclusion: Serum s(P)RR levels are significantly higher in hemodialysis patients when compared with subjects with normal renal function, although s(P)RR are dialyzed to some extent.