This finding correlated with the presence of myelopathy (P < 0.0001). Multivariate analysis on the subset with cord compression indicates that the likelihood of myelopathy increased with the presence of cord signal hyperintensity (odds ratio [OR], 11.4), sensory loss (OR, 16.9), and age (OR, 1.10 per year).

Conclusion. The diagnosis of cervical myelopathy is based on presenting symptoms and physical selleck kinase inhibitor examination. This analysis illustrates that radiographic cervical spinal cord compression and hyperintense T2 intraparenchymal

signal abnormalities correlate with the presence of myelopathic findings on physical examination.”
“Acanthus montanus, Alchornea laxiflora, Hyptis spicigera, Microglossa pyrifolia, Piliostigma reticulatum, and Voacanga africana were evaluated with respect to anticonvulsant and sedative activity in mice using animal models (maximal electroshock (MES), N-methyl-D-aspartate (NMDA), pentylenetetrazol (PTZ), isonicotinic hydrazide acid (INH). picrotoxin (PIC), and strychnine (STR)-induced convulsions or turning behavior and diazepam-induced sleep). Acanthus montanus protected 66.6% of mice against MES-, PIC-, and STR-induced convulsions and 83.3% of mice from PTZ-induced convulsions. Alchornea laxiflora protected 75% and 87.5% of mice in the STR and NMDA tests, respectively, at a dose of 120 mg/kg. Hyptis spicigera protected 100 and 87.5% of

mice against STR- and PTZ-induced convulsions, respectively, at a dose of 160 mg/kg. ARS-1620 mouse Microglossa pyrifolia protected 50% to 100% of mice against convulsions. Piliostigma reticulatum protected 62.5% to 100% of mice against convulsions and turning behavior. Voacanga africana protected BTSA1 ic50 62.5% to 87.5% of mice against convulsions and turning behavior. All of the plants except A. laxiflora also exerted sedative activity by strongly increasing the total duration of sleep induced by diazepam. (C)

2008 Elsevier Inc. All rights reserved.”
“Herein we report the electrosynthesis of polypyrrole with L-tryptophan (L-Trp) as a template to prepare molecularly imprinted polymers (MIPs). Overoxidized polypyrrole films with cavities complementary to the template were used for the enantioselective detection Of L-Trp and D-tryptophan (D-Trp). Important parameters, such as the electropolymerization potential, overoxidization potential and time, thickness of the polypyrrole films, and scanning rate of the stripping voltammetric experiments, were varied to achieve an optimum sensor response. We found that L-Trp was inserted about 2 times higher into the imprinted polymer film than DTrp. Also, in this study, an electrochemical quartz crystal microbalance technique was used to investigate the performance of overoxidized polypyrrole films. The enantioselectivity of the MIPs was attributed to the cavities in the imprinted films, which were complementary to the target molecules, both in shape and in positioning of the functional groups.