05; Table S2). Object-responsive activations within the grid were investigated by contrasting intact objects with their scrambled counterparts (Figure 5D; Table S2). In the control group, 66% ± 14%, and similarly in C1, 70% of the sectors in the RH showed object-related responses. Most of the sectors that were not responsive to the presentation of object stimuli were located in anterior and ventral sectors of the grid, thus in cortical regions that likely represent the periphery of the visual field. In SM, only 11% of the RH sectors showed object-related

responses. The number of activated sectors was significantly reduced in SM compared to the control group and to C1 (p < 0.05), but similar to healthy subjects, sectors that were not responsive were located anterior and ventral to the lesion and thus outside retinotopic cortex and selleck kinase inhibitor LOC. Object-selective responses were investigated in an fMR-A paradigm. For 2D and 3D objects and line drawings, the same object was presented 16 times in the adapted condition, while 16 different objects were presented ABT-263 mw once in the nonadapted condition. To investigate object-selective responses, we calculated an adaptation index (AI), which estimates the response difference between

the adapted and nonadapted conditions. A sample time course of fMRI signals for 2D objects is shown for SM in Figure S6. Figure 5E and Table S2 show the grid-sectors exhibiting object-selective responses in the control group, SM, and C1. In the group, 68% ± 13% of the grid in the RH showed object-selective responses,

and in C1, 61% of the grid in the RH showed object-selective responses, the majority of which were located in posterior and dorsal sectors of the grid Linifanib (ABT-869) and covered LOC. In SM, only 13% of the grid exhibited object-selective responses, which was significantly reduced compared to the control group and to C1 (p < 0.05). The sectors showing object-selective responses collectively covered LOC and were anatomically located dorsal to the lesion site. Patient SM’s LH was structurally intact, which allowed us to investigate whether a RH lesion of object-selective cortex may have consequences on anatomically equivalent locations in the contralesional hemisphere. To examine this issue, the four sectors of the rectangular grid covering the lesion in SM’s RH were centered on the posterior tip of the left lateral fusiform gyrus permitting the comparison of the lesioned RH and mirror-symmetric locations in the structurally intact LH (Figure 5A). Similar to the analysis of the RH, anatomically equivalent locations in the LH of control subjects were also probed.