Our results further suggest that virus-induced IFN does not contribute substantially to resistance of chickens against highly

pathogenic influenza viruses.”
“In humans, the diagnosis of PTSD is made only if an individual exhibits a certain number of symptoms from each of three quite well defined RepSox symptom clusters over a certain period of time. Animal behavioral studies, however, have generally tended to overlook this aspect and have commonly regarded the entire group of animals subjected to certain study conditions as homogeneous. Thus, in an attempt to develop animal models of long-term chronic behavioral responses to stress (i.e. PTSD) in a comparable manner to human diagnosis, we applied cut-off inclusion/exclusion criteria to behavioral data for a cohort of animals exposed to a stress paradigm. This grouped them as behaviorally affected or unaffected by the stress. This model takes into account the variability in degree of the individual’s response to the stress paradigm, thereby modeling the fact that not all humans exposed to traumatic stress respond with affective disorder. This article will present and discuss findings from a series of studies employing a model selleck screening library of individual behavioral response classification.

This article will discuss the concept of the model and its background and present a selection of studies employing and examining the model, alongside the underlying translational rationale of each. This article is part of a Special Issue entitled ‘Post-Traumatic Stress Disorder’. (C) 2011 Elsevier Ltd. All rights reserved.”
“Approximately Histamine H2 receptor 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms

(OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS + OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region.