164, p<0.001), NLR www.selleckchem.com/products/Pazopanib-Hydrochloride.html (r=0.517, p<0.001) and ESR (r=0.479, p<0.001) in patients with cerebral infarction. However, as all analysed parameters were not normally distributed, we considered it proper to interpret data by the Spearman correlation test. Both NLR and ESR were positively correlated with CRP in Pearson or Spearman correlation tests. This study might support further related studies dealing with an association between cerebral infarction and inflammation. Also, MPV, NLR and ESR should be further investigated for their ability to find the clinical impact of disease progression and expectation of mortality in patients with cerebral infarction. Up to date, the consensus diagnostic

cut-off ranges of MPV and NLR have not been established for evaluation of cerebral infarction. Furthermore,

platelet indices measure the femtolitre (10–15 L) levels and still have not been standardised; the results also vary from device to device.25 This study has some limitations such as the participants were retrospectively analysed for quite a long time (3 years and 8 months). We did not categorise specific cerebral infarction types and did not strictly exclude patients with additional disorders such as diabetes, cardiovascular diseases and malignant diseases, which might impact the level of enrolled parameters. In addition, MPV can be influenced by the time interval between sampling and analysis.26 MPV results become increasingly unreliable after 4 h.27 Complete blood count analysis in our laboratory has almost proceeded within 4 h from sampling start. In conclusion, we suggest the novel possibility that MPV and NLR may be useful parameters for

evaluating patients with cerebral infarction compared with CRP. Characteristically, MPV or NLR are inexpensive and simple parameters that can be attainable by using an automatic haematology analyser. Therefore, further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction. Supplementary Material Author’s manuscript: Click here to view.(1.6M, pdf) Reviewer comments: Click here to view.(135K, pdf) Footnotes Contributors: J-HL designed and participated in all stages of the study. K-YK Batimastat consulted diagnosis of patients. S-YY, H-SK and CSL helped with consultations for this study. Funding: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (No. 2008-0061891). Competing interests: None. Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: No additional data are available.
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