4%), which contained 6 frank perforation and 8 micro-perforation. Using the multivariate

analysis, perforation was associated with submucosal fibrosis (adjusted OR, 5.80; 95% CI, 1.28–26.32) and total procedure time (adjusted OR of of every 10 minutes increasement of total procedure, 1.12; 95%, 1.02–1.23). The ROC analysis for association between perforation learn more and procedure time showed AUC of 0.73 (95% CI: 0.60–0.86). According to the Youden index for total procedure time, optimal cutoff points may be set as ≥94.5 min (sensitivity, 78.6%; specificity, 68.3%). Conclusion: Total procedure time and submucosal fibrosis are independent predictors of perforation during ESD for superficial colorectal neoplasia ≥2 cm. Physicians should be aware of increased risk of perforation when ESD procedure time was greater than about ≥90 minutes. Key Word(s): 1. colorectal neoplasia; 2. endoscopic submucosal dissection; 3. perforation; 4. procedure time Presenting Author: CHARLES J. CHO

Additional Authors: JUNG HO BAE, DONG HOON YANG, JAE SEUNG SOH, SEOHYUN LEE, HO SU LEE, HYO JEONG LEE, Palbociclib mouse SANG HYOUNG PARK, KYUNG JO KIM, JEONG SIK BYEON, SEUNG JAE MYUNG, SUK KYUN YANG, JIN HO KIM Corresponding Author: CHARLES J. CHO Affiliations: Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center, Asan Medical Center Objective: Endoscopic submucosal dissection (ESD) has been widely accepted as a treatment option for early colorectal neoplasia (CRN). However, little is known about the optimal time to restart diet

after ESD. We aimed to investigate the optimal time to restart diet after ESD. Methods: We retrospectively reviewed medical records of 293 patients who underwent colorectal ESD without perforation between 2008 and 2013. These patients were divided into early (≤24 hours PAK5 after ESD) and late (>24 hours after ESD) diet group. Baseline characteristics, therapeutic outcomes of ESD, post-diet complications and duration of hospitalization were investigated. A propensity score for duration of NPO was constructed using multivariate logistic regression, and case-matching was performed to adjust the effect of selection bias. Results: Among 293 patients, 257 were early and 36 were late diet group. The baseline characteristics of the early diet group were as follows: mean age was 61.6 years and 152 (59.1%) were male. Mean size of the lesion was 31.3 mm. 109 (42.4%) of the lesions were located in the rectum. Mean NPO and hospitalization time after ESD were 16.6 and 23.7 hours, respectively. Post-diet complications were fever (n = 5, 1.9%), vomiting (n = 4, 1.4%), ileus (n = 10, 3.4%), abdominal pain (n = 3, 1.0%), and immediate post-procedural bleeding (n = 7, 2.7%). After discharge, 3 (1.