“
“Aim The purpose of this study was to compare the intraoperative and postoperative parameters among the three approaches used to treat large uterine myomas: laparoscopic assisted vaginal hysterectomy (LAVH), total laparoscopic hysterectomy (TLH) and abdominal hysterectomy, and to evaluate the selection criteria for laparoscopic hysterectomy as determined by magnetic resonance

imaging. Material and Methods The medical records of 155 patients who underwent a hysterectomy between January 2007 and April 2010 were examined. We also compared the indications and outcomes of LAVH and TLH for myomas larger than 7cm. Results Patients who underwent LAVH or TLH had a lower average intraoperative blood loss, less intense postoperative pain, and shorter hospital stays than patients in the TAH group, although the length of the operations in the laparoscopic groups were NF-��B inhibitor significantly

longer. To evaluate the selection criteria for the large sized myomas, we compared the LAVH and TLH groups for the myomas larger than 7cm. The greatest uterine transverse diameters and the weight of the uteri were not significantly selleck different between the LAVH and TLH groups (94.7 +/- 20.8 and 83.1 +/- 17.6mm, 371.6 +/- 160.3 and 286.7 +/- 158.0g, respectively). The average intraoperative blood loss in the TLH group was significantly lower than that in the LAVH (121.3 +/- 111.2 vs 379.3 +/- 222.4g, P<0.001). Conclusion Our data suggest that TLH is a better procedure for treating a large uterus no larger than 10cm

GDC-0994 purchase in its greatest transverse diameter. The preoperative total length of myoma nodules determined by MRI is a useful preoperative indicator of the uterine weight.”
“The effects of the flavonoid compound scutellarin (SCUT) on collagen biosynthesis, prolidase activity, expression of beta(1) integrin, insulin-like growth factor-I (IGF-I) receptor and the transcription factor NF-kappa B were evaluated in human dermal fibroblasts. Confluent fibroblasts were treated with micromolar concentrations (10-30 mu M) of SCUT for 24 h. It was found that a SCUT-dependent decrease in collagen biosynthesis was accompanied by an increase in prolidase activity. Since the IGF-I receptor (IGF-IR) is the most potent regulator of both collagen biosynthesis and prolidase activity, and prolidase is regulated by beta(1) integrin signalling, the effect of SCUT on IGF-IR and beta(1) integrin receptor expressions were evaluated. It was found that the exposure of the cells to SCUT contributed to an increase in IGF-IR and beta(1) integrin receptor expressions. This was accompanied by an increase in expression of NF-kappa B, the known inhibitor of collagen gene expression. These data suggest that the SCUT-dependent decrease of collagen biosynthesis in cultured human skin fibroblasts results from activation of NF-kappa B, which is responsible for the down-regulation of collagen gene expression.