Clin Cancer Res 2001, 7: 1204–1213.PubMed 60. Baselga J, Pfister D, Cooper MR, Cohen R, Burtness B, Bos M, D’Andrea G, Seidman A, Norton L, Gunnett K, Falcey J, Anderson V, Waksal H, Mendelsohn J: Phase I studies of anti-epidermal growth factor receptor chimeric antibody
C225 alone and in combination with cisplatin. J Clin Oncol 2000, 18: 904–914.PubMed 61. Park K, Chung F, Chun M, Suh F: Radiation-Induced Ling Disease and the impact of Radiation Methods in Imaging Features. RadioGraphics 2000, 20: 983–998. Competing Selleckchem Vactosertib interests The authors declare that they have no competing interests. Authors’ contributions JH conceived and designed the study and participated in writing. AA participated in data gathering, study screening, and study coordination. TD participated in data gathering, study screening, and study coordination. JL participated in statistical analysis of the study and study design. RW participated in study design and data analysis. ML performed oversight of study design, coordination, and writing. All authors MDV3100 in vitro read and approved the final manuscript.”
“Backgrounds Breast cancer is the second leading cause of cancer death in women, exceeded only by lung cancer in the world
. It is believed that some epidemic factors such as Oral contraceptive use ; obesity  and hyperinsulinemia  are probable factors increasing risks of developing breast carcinoma. Although many individuals exposed to
these risk factors, breast cancer develops only in a small group of exposed people, implying that genetic factors might contribute to the carcinogenic mechanisms and complex interactions between many genetic and environmental factors might be the major cause of breast cancer. Previously, a number of studies indicate that family history is a risk factor for breast cancer , indicating the possible roles for genetic variations on the increased susceptibility to breast cancer. Recent published meta-analyses suggest that polymorphisms of Fok1 , XRCC1 codon 399 and methylenetetrahydrofolate reductase might have a significant association with increased breast cancer risk. Nevertheless, conversely, selleck kinase inhibitor some meta-analysis failed to suggest a marked association of increased susceptibility to breast cancer with polymorphisms of some genes, such as Estrogen receptor alpha , CYP1A1  and base-excision PR-171 mw repair pathway genes . Recently, a growing body of research has conducted on the association of breast cancer risk with tumour suppressors. TP53, one of the most extensive studied genes as a tumor suppressor, has been thought to have a critical function in cell cycle regulation. In case of its mutation, this regulation could be lost, resulting in cell proliferation without control and development of cancer.