In this study, 41 children with spastic cerebral palsy were asses

In this study, 41 children with spastic cerebral palsy were assessed, and 56 normally developed children were included as control. Parameters such as body compositions, basal metabolic

rate, body resistance, liquid compartment, and capacitance of patients and control group were measured and analyzed statistically. Basal metabolic rate, body mass index, PXD101 clinical trial extracellular liquid, intracellular liquid, body capacitance, and resistance differed significantly compared to the control group (P < .01), whereas extracellular mass, lean body mass, body cell mass, and fat mass did not differ significantly compared to the control group (P > .05). Parameters such as basal metabolic rate, body composition, and body resistance can be determined using the bioelectrical impedance method in children with cerebral palsy.”
“Background & aims: The association of fatigue with decreased physical performance and underlying mechanisms are poorly understood in Crohn’s disease (CD). We aimed to measure and compare self-reported fatigue with skeletal muscle fatigue in CD subjects and healthy controls, and to identify associated

factors that may be amenable to change.

Methods: Demographic and clinical data were collected and fatigue assessed using the Fatigue Impact Scale (FIS) in 27 consecutive CD patients and 22 matched healthy controls. Circulating cytokines and growth factors were measured. Microbiology inhibitor The rate of quadriceps muscle fatigue

was assessed NVP-LDE225 ic50 using an isokinetic dynamometer as the decrement of force with 30 contractions performed over a 5-minute period.

Results: Compared with healthy controls, CD patients reported greater levels of fatigue (mean global FIS score 45.3 vs 10.5, physical dimension score 12.3 vs 2.7 respectively; each p < 0.01) and muscle fatigue (-5.2 vs -1.3 Nm min(-1); p < 0.05). The two indices were correlated (r = -0.52 in CD; p < 0.01). Patients with CD had lower mean serum IGF-1 levels (16.1 vs 25.4 pmol/L, p < 0.01) and higher oxidative stress (TBARS assay 4.3 vs 3.9 mu M, p < 0.05). On multivariate analysis, low serum vitamin D, IGF-1 and magnesium, and higher IL-6 levels were associated with increased muscle fatigue (all p <= 0.05).

Conclusion: Subjects with CD had more muscle fatigue than matched healthy controls and this correlated well with self-reported fatigue. Of circulating factors that were independently associated with increased muscle fatigue, vitamin D, magnesium and IGF-1 could be targeted in future studies to reduce fatigue and improve physical performance. Crown Copyright (C) 2013 Published by Elsevier B.V. on behalf of European Crohn’s and Colitis Organisation. All rights reserved.

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