Lancet 1981, i:653–656.CrossRef 27. Erkasap S, Ates E, Ustuner Z, Sahin A, Yilmaz S, Yasar B, et al.: Diagnostic value of interleukin-6 and Creactive protein in acute appendicitis. Swiss Surg 2000,6(4):169–172.PubMedCrossRef 28. Wu HP, Lin CY, Chang CF, Chang YJ, Huang CY: Predictive value of C-reactive protein at different cutoff levels in acute appendicitis. Am J Emerg Med 2005,23(4):449–453.PubMedCrossRef 29. Gronroos JM, Gronroos P: Leukocyte count and Creactive protein in the diagnosis of acute appendicitis. Br J Surg 1999,86(4):501–504.PubMedCrossRef 30. Eryilmaz R, Sahin M, Alimoglu O: The value of C-reactive

protein and leukocyte count in preventing negative appendectomies. Ulus Treuma Derg 2001, 713:142–145. 31. Grönroos JMJU: find more Do normal leukocyte count and C-reactive protein value exclude acute in children? Acta Paediatr 2001,90(6):649–5.PubMedCrossRef 32. Yokoyama S, Takifuji Tozasertib solubility dmso K, Hota T, Matsuda K, Nasu T, Nakamori M, Hirabayashi N, Kinoshita H, Yamaue H: C-Reactive protein is an independent surgical indication marker for appendicitis: a retrospective study. World J of Emergency EPZ015938 Surgery 2009, 4:36.CrossRef 33. Sinanan M, et al.: Acute Abdomen and Appendix. In Surgery; Scientific Principles and Practice. 4th edition. Edited by: Greenfield L. Philadelphia: J.B. Lippincot Company; 2005:1120–1142. 34. Eriksson S, Granstrom

L: Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis. Br J Surg 1995, 82:166–169.PubMedCrossRef 35. Styrud J, Eriksson S, Nilsson I, Ahlberg , Haapaniemi S, Neovius G, Rex L, Badume

I, Granstrom L: Appendectomy versus antibiotic treatment in acute appendicitis; a prospective multicenter randomized medroxyprogesterone trial. World J Surg 2006, 30:133–137.CrossRef 36. Exadactylos A, Sadowski-Cron C, Mader P, Weissmann M, Dinkel HP, Negri M, Zimmerman H: Decision making in patients with acute abdominal pain at a university and at a rural hospital: does the value of abdominal sonography differ? World Journal of Emergency Surgery 2008, 3:29.CrossRef 37. Leaper DJ, Horrocks JC, Staniland JR, De Dombal FT: Computer-assisted diagnosis of abdominal pain using “estimates” provided by clinicians. Br Med J 1972, 4:350–354.PubMedCrossRef 38. Kessler N, Cyteval C, Gallix B, Lesnik A, Blayac PM, Bruel JM, Taourel P: Appendicitis: Evaluation of sensitivity, specificity, and predictive values of US, Doppler US, and laboratory findings. Radiology 2004, 2:474–478. Competing interests The authors declare that they have no competing interests. Authors’ contributions SX designed the study, carried out acquisition, analysis, interpretation of the data, and drafting of the manuscript. LG-L analyzed histologically the removed appendixes. KX measured the Serum CRP. FV, BB, and FS participated in the study’s design. AK designed the study, was involved in interpretation of the data, the drafting of the manuscript, and revised it critically for the intellectual content until the final version was reached.