Main outcome measures: The primary outcome was accelerometry-deri

Main outcome measures: The primary outcome was accelerometry-derived proportion of children meeting the 30-minute/day moderate to vigorous physical activity policy. Results: Children attending intervention afterschool programs had an OR of 2.37 (95% CI = 1.58, 3.54) to achieve the physical activity policy at post-assessment compared to control afterschool programs. Sex-specificmodels indicated that the percentage of intervention girls and boys achieving the physical activity policy increased from 16.7% to 21.4% (OR = 2.85, 95% CI = 1.43, 5.68) and 34.2% to 41.6% (OR = 2.26, 95%

CI = 1.35, 3.80), respectively. At post-assessment, six intervention afterschool MX69 mw programs increased the proportion of boys achieving the physical activity policy to Pevonedistat bigger

than = 45% compared to one control afterschool program, whereas three intervention afterschool programs increased the proportion of girls achieving physical activity policy to bigger than = 30% compared to no control afterschool programs. Conclusions: The Strategies To Enhance Practice intervention can make meaningful changes in the proportion of children meeting the moderate to vigorous physical activity policy within one school year. Additional efforts are required to enhance the impact of the intervention. (C) 2015 American Journal of Preventive Medicine”
“Assessment of minimal residual disease (MRD) is becoming standard diagnostic care for potentially curable neoplasms such as acute lymphoblastic leukemia. In multiple myeloma (MM), the majority of patients will inevitably relapse despite achievement of progressively higher complete remission (CR) rates. Novel treatment protocols with inclusion of antibodies and small molecules might well be able to further increase remission rates and potentially also cure rates. Therefore, MRD diagnostics

becomes essential to assess treatment effectiveness. This review summarizes reports from the past 2 decades, which demonstrate see more that persistent MRD by multiparameter flow cytometry, polymerase chain reaction, next-generation sequencing, and positron emission tomography/computed tomography, predicts significantly inferior survival among CR patients. We describe the specific features of currently available techniques for MRD monitoring and outline the arguments favoring new criteria for response assessment that incorporate MRD levels. Extensive data indicate that MRD information can potentially be used as biomarker to evaluate the efficacy of different treatment strategies, help on treatment decisions, and act as surrogate for overall survival.

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