Marsbar was used to extract estimates in each gyrus for the contrast of abstract versus concrete words. Analyses to this point were targeted on specific frontal and temporal areas. To allow comparison with previous studies, we performed an INCB024360 additional whole-brain analysis comparing concrete with abstract words. We also compared the pattern of

concreteness effects with areas of task-related activation and deactivation (i.e., the contrast of the semantic conditions vs fixation). Previous studies have reliably identified the angular gyrus and posterior cingulate as showing a C > A activation pattern ( Binder et al., 2005, Sabsevitz et al., 2005 and Wang et al., 2010). These areas are associated with the default mode network that typically deactivates during stimulus-driven processing ( Buckner et al.,

2008), as are anterior temporal regions, raising the possibility effects in these areas may relate to differential deactivation rather than task-related increases in activity. To explore this possibility, ROI analyses were conducted for key regions identified in the C > A contrast, based on 5 mm spheres centred on peak co-ordinates. Mean error rates and reaction times in each condition are shown in Table 3. Performance on the number baseline task was comparable to that of Talazoparib the more difficult semantic conditions, confirming that the number task was a suitable baseline for controlling for effects of working memory and attention

associated with general cognitive processing. Reaction time data for the semantic task were analysed using a 2 × 2 repeated-measures ANOVA. This revealed main effects of concreteness [F(1,18) = 237, p < .001] and cue type [F(1,18) = 155, p < .001]. Abstract words were processed more slowly than concrete words and participants were slower Amine dehydrogenase when the judgement was preceded by an irrelevant, rather than contextually appropriate cue. There was also a significant interaction between concreteness and cue type [F(1,18) = 25.7, p < .001], indicating that the presence of contextual cues benefited abstract words to a greater degree than concrete words. Analysis of error rates replicated these effects [concreteness: F(1,18) = 66, p < .001; cue type: F(1,18) = 45, p < .001; interaction: F(1,18) = 25.1, p < .001]. These effects confirm that the presence of contextual cues aided semantic decisions, presumably by reducing the need for semantic control, and that this benefit was most pronounced for abstract words, which tend to have more variable, context-dependent meanings. The whole-brain analysis of semantics > numbers revealed a number of peaks in left-hemisphere frontal and temporal regions associated with semantic processing (see Fig. 2; MNI co-ordinates are reported in Table 4).