Nature 2001, 411:349–354.PubMedCrossRef INCB28060 21. Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG: Side population is enriched in tumorigenic, stem-like cancer cells, whereas abcg2+ and abcg2 cancer cells are similarly tumorigenic. Cancer Res 2005, 65:6207–6219.PubMedCrossRef 22. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor

growth and angiogenesis through elevated sdf-1/cxcl12 secretion. Cell 2005, 121:335–348.PubMedCrossRef 23. Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB, Logsdon CD: Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 2008, 68:918–926.PubMedCrossRef 24. Serini G, Gabbiani G: Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res 1999, 250:273–283.PubMedCrossRef 25. Mueller MM, Fusenig NE: Friends

or foes – bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004, 4:839–849.PubMedCrossRef 26. Balkwill F: Cancer and the chemokine network. Nat Rev Cancer 2004, 4:540–550.PubMedCrossRef 27. Wang Z, Ma Q, Liu Q, Yu H, Zhao L, Shen S, Yao J: Blockade of sdf-1/cxcr4 signalling LY2874455 supplier inhibits pancreatic cancer progression in vitro via inactivation of canonical wnt pathway. Br J Cancer 2008, 99:1695–1703.PubMedCrossRef 28. Lapteva N, Yang AG, Sanders DE, Strube RW, Chen SY: Cxcr4 knockdown by small interfering rna abrogates breast tumor growth in vivo. Cancer

Gene Ther 2005, 12:84–89.PubMedCrossRef 29. Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD: Cxcr4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004, 64:8604–8612.PubMedCrossRef 30. Dillmann F, Veldwijk MR, Laufs S, Sperandio M, Calandra G, Wenz F, Zeller WJ, Fruehauf S: Plerixafor inhibits chemotaxis toward sdf-1 and cxcr4-mediated stroma contact in a dose -dependent manner resulting in increased susceptibility of bcr-abl(+) cell to imatinib oxyclozanide and nilotinib. Leuk Lymphoma 2009, 1–11. 31. Katayama A, Ogino T, Bandoh N, Nonaka S, Harabuchi Y: Expression of cxcr4 and its down-regulation by ifn-gamma in head and neck squamous cell carcinoma. Clin Cancer Res 2005, 11:2937–2946.PubMedCrossRef 32. Salvucci O, Basik M, Yao L, Bianchi R, Tosato G: Evidence for the involvement of sdf-1 and cxcr4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by tnf-alpha and ifn-gamma. J Leukoc Biol 2004, 76:217–226.PubMedCrossRef 33. Marchesi F, Monti P, Leone BE, Zerbi A, Vecchi A, Piemonti L, Mantovani A, Allavena P: Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional cxcr4. Cancer Res 2004, 64:8420–8427.PubMedCrossRef 34.