Novel serological markers are required for the diagnosis of
prostate cancer, and more importantly, to diagnose potentially lethal forms of the disease. Auto-antibodies against CIP2A were detected in 13%, 5% and 3% of the sera of hepatocellular, gastric GSK1904529A chemical structure and esophageal carcinomas, respectively [8]. Subsequently, similar auto-antibodies were detected more frequently (30%) in the sera of prostate cancer patients, while only rarely (1.5%) in BPH patients. Furthermore, CIP2A auto-antibodies were present more frequently (29% vs. 16%) in the sera of prostate cancer patients with a high Gleason score (seven or higher) when compared to patients with less aggressive disease [6]. These data with the present results suggest that evaluation of CIP2A and/or the auto-antibody concentrations against it may help in the identification of aggressive prostate cancer. We studied CIP2A expression by immunohistochemistry only, which is a limitation of the present study. However, immunohistochemistry detects the expression of the functional gene product, CIP2A protein, and https://www.selleckchem.com/products/BKM-120.html measuring RNA expression levels are not always congruent with those of the protein. To this end, since our results show significant association of CIP2A FK228 protein expression with relevant clinicopathological variables,
our data are important and suggest a novel link between the oncogenic CIP2A and carcinogenesis of Tacrolimus (FK506) the
prostate. Conclusions We showed that expression of the CIP2A protein is increased in aggressive forms of prostate cancer. Further studies are required to demonstrate the prognostic role of CIP2A in prostate cancer and its value in the identification of aggressive disease forms. Acknowledgements We would like to thank Ms Mirja Vahera and Ms Erja Tomperi for their skilful technical assistance. Pasi Ohtonen, M.Sc. is acknowledged for his invaluable assistance with statistical analyses. MHV was supported by the Finnish Medical Fund. References 1. Eichhorn PJ, Creyghton MP, Bernards R: Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta 2009, 1795: 1–15.PubMed 2. Junttila MR, Puustinen P, Niemela M, Ahola R, Arnold H, Bottzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grenman R, Kast J, Kallunki T, Sears R, Kahari VM, Westermarck J: CIP2A inhibits PP2A in human malignancies. Cell 2007, 130: 51–62.PubMedCrossRef 3. Li W, Ge Z, Liu C, Liu Z, Bjorkholm M, Jia J, Xu D: CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res 2008, 14: 3722–3728.PubMedCrossRef 4.