We focused on doing different autonomic disorder tests within the assessment of someone with recurrent orthostatic hypotension. We suspect that pure autonomic failure may possibly not have been considered when you look at the differential diagnosis of recurrent orthostatic hypotension and declare that it is Stroke genetics to be kept as a differential this kind of a scenario. Midodrine has a fruitful role in syncope as a result of sympathetic vasoconstrictor failure.Paraurethral genital leiomyoma could be the infrequent situation become explained. About 300 cases have now been described up to now. Imaging modalities assist in pinpointing the morphological, structural faculties for the size and its particular commitment towards the surrounding frameworks. Thirty-six yrs old wedded women presented with a vulvar size of (3×5) cm2. Her connected complaints were left shift of this urinary stream and dyspareunia. Ultrasonography and cystography disclosed a mass without any relationship with bladder or uterine structure. Surgical excision had been done. The histopathological report verified the diagnosis of paraurethral vaginal leiomyoma. Surgical excision could be the treatment of option and diagnosis is verified by histopathological assessment. Psychoactive compound use among health students is typical. This might not just pose a threat to their health insurance and educational overall performance but might have medico-legal and ethical implications. The purpose of this research would be to determine the prevalence of six psychoactive substances (alcoholic beverages, tobacco, cannabis, cocaine, benzodiazepines, opioids) among 2nd 12 months and 3rd year medical pupils. A descriptive cross-sectional research Akt inhibitor ended up being done in a health university. Entire sampling was done and moral endorsement ended up being obtained from the Institutional Assessment Committee (research quantity 54-074/075). The study had been performed from May 2018 to Summer 2018. A semi-structured self-administered questionnaire altered and adapted from World Health corporation’s instructions for student material use survey had been utilized to get information from second year and third 12 months medical students. Statistical Package for Social Sciences version 16.0 was useful for analysis. Aim estimation at 95% self-confidence Interval was computed along side frequency and proportion for binary information. Very nearly half of the pupils were currently utilizing a number of psychoactive substances which is regarding, and so techniques needs to be used to ease such use.Practically half of the students were presently making use of several psychoactive substances which is concerning, and as a consequence methods needs to be used to alleviate such use. COVID 19 vaccination will protect us from getting COVID-19. Some unwanted effects are normal which are signs that our human anatomy is creating security. This complications will disappear in a few days. The goal of this study will be find out side effects seen among medical care workers after 2nd dose of covishield vaccination. This was a descriptive cross-sectional research conducted at Kathmandu medical college and training Hospital from 22nd April 2021 till 30th April 2021. Ethical endorsement was revceived from Institutional Commitee of Institiute. Convienient sampling had been done. The 2nd dose of covishield vaccine was administered 12 months following its very first dosage. The vaccine ended up being administered intramuscularly (IM) into deltoid muscle. Statistical Package for the Social Sciences were used for analysis. Away from 220 cases taken, 135 had been male and 85 had been female. Within our research 178 (80.90%) problem of pain at injection site after second dosage of covishield vaccine accompanied by 97 (44.09%) complaint of weakness, 43 (19.54percent) problem of stress, 18 (8.18%) grievance of chills, 11 (5.00%)complaint of fever, 6 (2.72%) problem of dizziness and 5 (2.27%) problem of sickness.Soreness at shot site, fatigue and hassle had been common side effects seen after second dosage of Covishield vaccination.Body packing is the process of smuggling illicit drugs in the shape of plans concealed inside the gastrointestinal area via ingestion or inserting into human anatomy orifices. Him or her are called “body packers”, “stuffers”, “mules” or “swallowers” and resort to carrying drugs like heroin, cocaine and cannabis. They give a medical facility following the improvement precise medicine complications or brought lifeless due to the rupture of packets or right from detention for additional investigations. This case illustrates a suspected case detained through the airport who had been found to be carrying 93 pellets of an illicit drug, heroin, evaluating 900 grms, one of many greatest quantity carried by any body packer in the united states till time. This case additional sheds light on the proven fact that a meticulous history, detailed medical assessment and radiographic investigations like abdominal radiograph and imaging would be the secrets to identify human anatomy packers in a resource minimal setting.Severe coronavirus disease 2019 are associated with modern respiratory failure. In addition to respiratory support as well as other supportive attention, utilization of corticosteroids has revealed to improve result.