Table selleck chemicals llc 2Underlying conditions and mechanism for patients with acute lung injury/acute respiratory distress syndromeComparison of extravascular lung water index and pulmonary vascular permeability indexThe EVLWI on the day of enrollment was significantly higher in ALI/ARDS patients than in patients with pleural effusion with atelectasis (18.5 �� 6.8 vs. 8.3 �� 2.1; P < 0.01) or cardiogenic edema (14.4 �� 4.0; P < 0.01) (Figure (Figure2).2). The PVPI on the day of enrollment was higher in the ALI/ARDS patients than in cardiogenic edema or pleural effusion with atelectasis patients (3.2 �� 1.4, 2.0 �� 0.8, and 1.6 �� 0.5, respectively). Although the EVLWI was higher in the cardiogenic edema than in pleural effusion with atelectasis patient (Figure (Figure2),2), there was no significant difference in PVPI between those groups (Figure (Figure33).

Figure 2Comparison of extravascular lung water indexed to predicted body weight. Comparison of extravascular lung water indexed to predicted body weight of patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), cardiogenic edema, and …Figure 3Comparison of pulmonary vascular permeability index. Comparison of pulmonary vascular permeability index (PVPI) of patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), cardiogenic edema, and pleural effusion with atelectasis …These differences were also noted when the maximal values of EVLWI and PVPI recorded during the study period were compared among the three groups (Figures (Figures22 and and33).

Relationship among EVLWI, PVPI, and intrathoracic blood volumeFor this analysis, cardiogenic edema and pleural effusion with atelectasis patients were considered non-ALI/ARDS patients because increased pulmonary vascular permeability is not the pathogenetic mechanism of these conditions and was not elevated compared with that in ALI/ARDS patients.In the ALI/ARDS patients, a strong correlation between EVLWI and PVPI (r = 0.729, P < 0.01) and a weak correlation between EVLWI and ITBV (r = 0.236, P < 0.01) were noted on the day of enrollment (Figure (Figure4).4). In the non-ALI/ARDS patients, moderate correlations between EVLWI and PVPI (r = 0.464, P < 0.01) and between EVLWI and ITBV (r = 0.493, P < 0.01) were noted (Figure (Figure55).Figure 4Extravascular lung water index and pulmonary vascular permeability index/intrathoracic blood volume correlation in ALI/ARDS patients.

Correlation between extravascular lung water index (EVLWI) and pulmonary vascular Entinostat permeability index (PVPI) and that …Figure 5Extravascular lung water index and pulmonary vascular permeability index/intrathoracic blood volume correlation in non-ALI/ARDS patients. Correlation between extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) and that …