The primary end point was defined as complete wound closure. Secondary end points comprised bleeding complications, amputation, and death.

Results: The study evaluated 15 patients with 17 Szilagyi III groin infections. Mean total length of VAC therapy was 43 days (range, 14-76 days). Mean time until complete healing was 51 days (range, 24-82 days). Mean length IWR-1 mw of VAC therapy in the hospital was 21 days (range, 5-61 days). Eleven patients received continued VAC treatment at home

for a mean length of 22 days (range, 5-69 days). Complete healing was achieved in 14 groins (82%). Three failures due to persisting infection, persisting necrosis, and a pseudomonas infection were noted. No bleeding complications, amputations, or late reinfections occurred. Median follow-up was 380 days (range, 56-939 days). Despite therapy failure, all 17 grafts were preserved.

Conclusions: VAC therapy on an exposed prosthetic vascular graft in the groin is safe

and feasible when applying a combination of polyvinyl alcohol and polyurethane foam dressing and 50 mm Hg of continuous negative pressure, resulting in midterm graft preservation. (J Vasc Surg 2012;56:714-20.)”
“Switching between responses is a key executive function known to rely on the frontal cortex and the basal ganglia. Here we aimed to establish with greater anatomical specificity whether such switching could be mediated via different possible frontal-basal-ganglia circuits. Accordingly, we stimulated dorsal vs. ventral contacts of electrodes in the subthalamic nucleus (STN) in Parkinson’s patients during switching performance, and also studied matched controls. The patients Idasanutlin in vivo underwent three sessions: once with bilateral dorsal contact stimulation, once with bilateral ventral contact stimulation, and once Off stimulation. Patients Off stimulation showed abnormal patterns of switching, and stimulation of the ventral contacts but not the dorsal contacts normalized the pattern of behavior Copanlisib relative to controls. This provides

some of the first evidence in humans that stimulation of dorsal vs. ventral STN DBS contacts has differential effects on executive function. As response switching is an executive function known to rely on prefrontal cortex, these results suggest that ventral contact stimulation affected an executive/associative cortico-basal ganglia circuit. (C) 2013 Elsevier Ltd. All rights reserved.”
“Objective: Medial arterial calcification (MAC) is common in diabetes, has a characteristic appearance on X-ray imaging, and has been linked with peripheral arterial stiffness and cardiovascular disease. However, few studies have measured X-ray MAC. It has been suggested that an ankle-brachial index (ABI) >1.30 or an ankle-brachial difference (ABD) >75 mm Hg may identify X-ray MAC, but test characteristics are unknown. We hypothesized that an ABI >1.30 and ABD >75 mm Hg would have high specificity but low sensitivity for MAC on X-ray imaging.