The yield of fVL testing in women with previous adverse pregnancy outcomes is up to six times higher than in the general population. Calculated post-test probabilities illustrate that the combined effect of fVL and poor pregnancy history places these women at a high-risk of recurrent events. The results to date of low molecular weight heparin (LMWH) treatment trials
cannot buy MK-0518 be extrapolated to all women with thrombophilia; however, the results provide a rationale for randomized prophylactic anticoagulant treatment trials in thrombophilic women with severe adverse pregnancy outcomes. While we await the results of well-designed, adequately powered treatment trials, we propose that post-test probabilities, in addition to the preliminary treatment data in high-risk women, justify consideration of screening for fVL in women with a strong past history of poor pregnancy outcome.”
“Purpose of review
To update the reader on immunogenetic advances in idiopathic
inflammatory myopathy (IIM) over the past 18 months.
Recent findings
In Caucasian IIM, despite a shared association with the human leukocyte antigen (HILA) 8.1 ancestral haplotype (HLA-DRB1*03-DQA1*05-DQB1*02), anti-Jo-1 and anti-PM-Scl anti body-positive cases have differing IN clinical phenotypes. A study of the HLA-DPB1 region has shown that DPB1*0101 is associated with anti-Jo-1 positivity but not with anti-PM-Scl. IN single nucleotide polymorphism studies have demonstrated HM781-36B nmr associations in the protein tyrosine phosphatase, nonreceptor type 22, tumour necrosis factor alpha and interleukin-1 genes. The GM 13 allotype has been confirmed as a risk factor in Caucasian IIM. In inclusion body myositis, the HLA 8.1 ancestral haplotype may find more not only influence disease susceptibility but also disease expression. A follow-up study including a meta-analysis of the apolipoprotein E gene in inclusion body myositis suggests
that this gene does not confer risk of disease.
Summary
Although a substantial part of the genetic risk for developing adult and juvenile IN lies within the major histocompatibility complex, recent research suggests that genetic regions outside of the major histocompatibility complex are also potentially involved in conferring IN disease susceptibility, although with more modest effect sizes. An ongoing and internationally coordinated IN genome-wide association scan may provide further insights into IN immunogenetics.”
“Motion occurring during magnetic resonance imaging acquisition is a major factor of image quality degradation. Self-navigation can help reduce artefacts by estimating motion from the acquired data to enable motion correction.