These aromatic polyimides were further acrylated via a reaction with acryloyl chlroride in the presence of triethyl amine to produce negative photoinitiator-free PSPIs. All the photoinitiator-free photosensitive

polyimides were characterized by FTIR and NMR while their morphologhy was evaluated by X-ray diffractions study. These newly synthesized PSPIs were evaluated to determine their electrical, thermal, and photolithographic properties. The PSPI (AHHFP-BTDA-6FDA [1 : 0.5 : 0.5]) with high mole ratio of 6FDA showed lower dielectric constants of 2.420 at 1 kHz and 2.170 at 1 MHz in capacitance and optical methods, respectively. Further, the acrylated FG-4592 AHHFP-BTDA showed the highest photosensitivity than other PSPIs. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 2937-2945, 2010″
“Background: Multiple myeloma

is an incurable disease. Little is known about the genetic and molecular mechanisms governing the pathogenesis of multiple myeloma. The risk of multiple myeloma predispositions varies among different ethnicities. More than 50% of myeloma cases showed normal U0126 karyotypes with conventional cytogenetic analysis due to the low mitotic activity and content of plasma cells in the bone marrow. In the present study, high resolution array comparative genomic hybridization technique was used to identify copy number aberrations in 63 multiple myeloma patients of Malaysia.

Results: Copy number aberrations were identified in 100% of patients selleck kinase inhibitor analyzed (n = 63). Common chromosomal gains were detected at regions 1q, 2q, 3p, 3q, 4q, 5q, 6q, 8q, 9q, 10q, 11q, 13q, 14q, 15q, 21q and Xq while common chromosomal losses were identified

at regions 3q and 14q. There were a total of 25 and 5 genes localized within the regions of copy number gains and losses, respectively (>30% penetrance). The LYST, CLK1, ACSL1 and NFKBIA are genes localized within the copy number aberration regions and they represent novel information that has never been previously described in multiple myeloma patients.

Conclusions: In general, due to the differences in genetic background, dietary and lifestyle practices of Malaysian compared to the Caucasian population, these chromosomal alterations might be unique for Asian MM patients. Genes identified in this study could be potential molecular therapeutic targets for the treatment and management of patients with multiple myeloma.