Virology 2002,296(1):84–93.PubMedCrossRef 17. Machida K, Tsukiyama-Kohara K, Seike E, Tone S, Shibasaki F, Shimizu M, Takahashi H, Hayashi Y, Funata N, Taya C, Yonekawa H, Kohara M: Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. J Biol Chem 2001,276(15):12140–12146.PubMedCrossRef 18. Hahn CS, Cho YG, Kang BS, Lester IM, Hahn YS: The HCV core protein acts as a positive regulator of fas-mediated apoptosis
in a human lymphoblastoid T cell line. Virology 2000,276(1):127–137.PubMedCrossRef 19. Ray RB, Meyer K, Steele R, Shrivastava A, Aggarwal BB, Ray R: Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein. J Biol Chem 1998,273(4):2256–2259.PubMedCrossRef 20. Ruggieri A, Harada T, Matsuura Y, Miyamura T: Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology 1997,229(1):68–76.PubMedCrossRef Wnt antagonist 21. Dumoulin FL, vsn dem Bussche A, Sohne J, Sauerbruch T, Spengler U: Hepatitis C virus core protein does not inhibit apoptosis in human hepatoma cells. Eur J Clin Invest 1999,29(11):940–946.PubMedCrossRef 22. Kalkeri G, Khalap N, Garry RF, Fermin
CD, Dash S: Hepatitis C virus protein expression induces apoptosis in HepG2 cells. Virology 2001,282(1):26–37.PubMedCrossRef this website 23. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RN, inhibitor Phillipsk MJ, Portmannl BG, Poulsenm H, Scheuer PJ, Schmidn M, Thalero H: Histological grading and staging of chronic hepatitis. J Hepatol 1995,22(6):696–699.PubMedCrossRef 24. Hamilton SRAL: World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. IARC Press, Lyon; 2000:157–202. 25. Seipp S, Mueller HM, Pfaff E, Stremmel W, Theilmann L, Goeser T: Establishment of persistent hepatitis C virus infection and replication in vitro. J Gen Virol 1997,78(Pt 10):2467–2476.PubMed 26. El-Awady MK, Tabll AA, el-Abd YS, Bahgat MM, Shoeb HA, Youssef SS, Bader el-Din
NG, Redwan el RM, el-Demellawy M, Omran MH, et al.: HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro. World J Gastroenterol 2006,12(30):4836–4842.PubMed 27. Zekri AR, El-Din HM, Bahnassy AA, Khaled MM, Omar A, Fouad I, El-Hefnewi M, Thakeb F, El-Awady M: Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4. Virol J 2007, 4:16.PubMedCrossRef 28. Zekri AR, Bahnassy AA, El-Din HM, Salama HM: Consensus siRNA for inhibition of HCV genotype-4 replication. Virol J 2009, 6:13.PubMedCrossRef 29. Joyce MA, Walters KA, Lamb SE, Yeh MM, Zhu LF, Kneteman N, Doyle JS, Katze MG, Tyrrell DL: HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice.