“
“Fronto-orbital advancement is an established method for correction of metopic and coronal craniosynostoses. Many techniques involve creation of a single fronto-orbital bar that is then shaped with osteotomies with or without bone grafting. We INCB024360 cost present a technique that minimizes osteotomy of the frontal bar and gives superior lateral brow aesthetics.

Standard fronto-orbital bar bone cuts are made without a midline osteotomy. Selective inner table corticectomy of the fronto-orbital bar allows

the bone to become malleable without greensticking. The need for osteotomy of the fronto-orbital bar is obviated. An additional bandeau is created from the temporoparietal calvaria. The malleable fronto-orbital bar is then fixed to this bandeau. The frontal bar and bandeau complex is then advanced in a conventional manner. The remaining frontal calvaria is then rotated creating a more vertical forehead.

This technique has been used in Leeds for more than 10 years with good cosmetic results. It has become our standard method for management

c-Met inhibitor of the fronto-orbital bar in correction of nonsyndromic metopic and coronal craniosynostoses.”
“Propranolol hydrochloride was directly encapsulated in alginate gel microspheres (40-50 mu m in diameter) using a novel method involving impinging aerosols of CaCl2 cross-linking solution and sodium alginate solution containing the drug. Microspheres formulated using 0.1M CaCl2 exhibited the highest drug loading (14%, w/w of dry microspheres) with 66.5% encapsulation efficiency. Less than 4% and 35% propranolol release occurred

from hydrated and dried microspheres, respectively, in 2 h in simulated gastric fluid (SGF). The majority of the drug load (90%) was released in 5 and 7 h from hydrated and dried microspheres, respectively, in simulated intestinal fluid (SIF). Prior incubation of hydrated www.selleckchem.com/products/BKM-120.html microspheres (cross-linked using 0.5M CaCl2) in SGF prolonged the time of release in SIF to 10 h, which has implications for the design of protocols and correlation with in vivo release behaviour. Restricted propranolol release in SGF and complete extraction in SIF demonstrate the potential of alginate gel microspheres for oral delivery of pharmaceuticals.”
“Spatially resolved mass spectrometry (MS) is a widespread technique increasingly used in many areas of research. Operating in a fast, straightforward way with minimal sample damage, MS investigation can provide spatially resolved information with low limits of detection and a wide linear range. For these reasons, spatially resolved MS is applied in the study of art and archaeological objects, and the current review provides a survey of relevant publications. We highlight the main capabilities and the limitations of spatially resolved MS and discuss the most relevant applications. (C) 2011 Elsevier Ltd. All rights reserved.