Highest prevalence of NAFLD was seen among Indian and Malay males at 33.3 XL184 % and 25.5 %, respectively. The prevalence of NAFLD among Chinese males was 6.8 %. Independent factors associated with NAFLD were: age, male gender, obesity and elevated serum ALT level. Conclusion: The particularly high prevalence of NAFLD among Indian and Malay males is observed as early as young adulthood and is consistent with the higher prevalence of obesity in these groups. Key

Word(s): 1. NAFLD; 2. ethnicity; 3. young adult; 4. epidemiology; Presenting Author: WAH KHEONG CHAN Additional Authors: ALEXANDER TONG BOON TAN, SHIREENE RATNA VETHAKKAN, PEI CHIEN TAH, ANUSHYA VIJAYANANTHAN, KHEAN LEE GOH Corresponding Author: WAH KHEONG CHAN Affiliations: University of Malaya Objective: Non-alcoholic fatty liver disease (NAFLD) has been associated with increased cardiovascular diseases independent of traditional risk factors for atherosclerosis. We embarked on buy RXDX-106 this study to determine if ultrasonography-diagnosed

NAFLD is associated with prevalent ischemic heart disease (IHD) among diabetics in a hospital clinic setting. Methods: This is a cross-sectional study on consecutive patients seen at the Diabetic Clinic of University of Malaya Medical Centre. Diagnosis of NAFLD was by ultrasonography following exclusion of significant alcohol intake and other causes of chronic liver disease. The medical record for each patient was reviewed for documented IHD. Patients without documented IHD but had symptoms and/or electrocardiographic changes suggestive of IHD were referred for cardiac evaluation. Results: Data for 399 patients were analyzed. Mean age was 62.8 ± 10.5 years with 43.1% male. Mean duration of diabetes mellitus was 16.2 ± 9.7 years and mean serum HbA1c level was 8.1 ± 1.8%. NAFLD and IHD were present in 49.6% and 26.6%, respectively. Ultrasonography-diagnosed NAFLD and serum ALT and GGT levels

were not associated with IHD. The prevalence of IHD was highest among the Indians (34.1%) followed by the Malays (29.2%) and the Chinese (20.1%). No association Thymidylate synthase was found between ultrasonography-diagnosed NAFLD or serum ALT and GGT levels and IHD when analyzed according to ethnicity. On multivariate analysis, independent factors associated with IHD were older age, lower levels of physical activity, greater waist circumference and higher serum glycated hemoglobin level. Conclusion: Ultrasonography-diagnosed NAFLD was not associated with prevalent IHD among long-standing poorly-controlled diabetics. Better characterization of NALFD using non-invasive methods may allow more accurate risk stratification for cardiovascular disease. Key Word(s): 1. NAFLD; 2. IHD; 3. diabetes mellitus; Presenting Author: ROMMELPARULAN ROMANO Additional Authors: MELCHORMESA CHAN, CARMELITADADO DALUPANG, CHANDY LOUPATIAG MALONG, ABIGAIL MILO, MARIO MILO Corresponding Author: ROMMELPARULAN ROMANO Affiliations: University of Santo Tomas Hospital Objective: Background.