Proc Natl Acad Sci USA 2004,101(13):4525–4530.CrossRefPubMed 7. Parsons AB, Z-IETD-FMK purchase Brost RL, Ding H, Li Z, Zhang C, Sheikh B, Brown GW, Kane PM, Hughes TR, Boone C: Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol 2004,22(1):62–69.CrossRefPubMed 8. Parsons
AB, Lopez A, Givoni IE, Williams DE, Gray CA, Porter J, Chua G, Sopko R, Brost RL, Ho CH, Wang J, Ketela T, Brenner C, Brill JA, Fernandez GE, Lorenz TC, Payne GS, Ishihara S, Ohya Y, Andrews B, Hughes TR, Frey BJ, Graham TR, Andersen RJ, Boone C: Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast. Cell 2006,126(3):611–625.CrossRefPubMed 9. Rine J, Hansen W, Hardeman E, Davis RW:
Targeted selection of recombinant clones through gene dosage effects. Proc Natl Acad Sci USA 1983,80(22):6750–6754.CrossRefPubMed 10. Orrenius S: Reactive oxygen CP-690550 supplier species in mitochondria-mediated cell death. Drug Metab Rev 2007,39(2–3):443–455.CrossRefPubMed 11. Leist M, Jaattela M: Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001,2(8):589–598.CrossRefPubMed 12. Gassner NC, Tamble CM, Bock click here JE, Cotton N, White KN, Tenney K, St Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS: Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay. 5-FU cell line J Nat Prod 2007,70(3):383–390.CrossRefPubMed 13. Canadian Chemical Biology Network[http://www.ccbn-rcbc.ca/] 14. Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, Hieter P, Boeke JD: Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids
for PCR-mediated gene disruption and other applications. Yeast 1998,14(2):115–132.CrossRefPubMed 15. Decottignies A, Rogers B, Kolaczkowski M, Carvajal E, Balzi E, Gwenaelle C, Kyoko N, Di Pietro A, Monk BC, Goffeau A: The Pleitropic Drug ABC Transporters from Saccharomyces cerevisiae. Horizon Scientific Press 2002. 16. Slonimski PP, Tzagoloff A: Localization in yeast mitochondrial DNA of mutations expressed in a deficiency of cytochrome oxidase and/or coenzyme QH2-cytochrome c reductase. Eur J Biochem 1976,61(1):27–41.CrossRefPubMed 17. Moye-Rowley WS: Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae. Gene 2005, 354:15–21.CrossRefPubMed 18. Chen JK, Lane WS, Schreiber SL: The identification of myriocin-binding proteins. Chem Biol 1999,6(4):221–235.CrossRefPubMed 19. Roskelley CD, Williams DE, McHardy LM, Leong KG, Troussard A, Karsan A, Andersen RJ, Dedhar S, Roberge M: Inhibition of tumor cell invasion and angiogenesis by motuporamines. Cancer Res 2001,61(18):6788–6794.PubMed 20.