The structure of the new compound was elucidated as Z-hex-3-en-1-ol O-alpha-L-arabinopyransyl (1”-2′)-beta-D-glucopyranoside (1) on the basis of spectroscopic

analysis and chemical evidence. The two known compounds were identified as ent-15-hydroxy-kaur-16-en-19-oic acid (2) Selleck eFT-508 and ent-18-hydroxy-kaur-16-en-19-oic acid (3) by comparison of their spectral data with the reported data. Compounds 2 and 3 were isolated for the first time from the title plant.”
“Background There is an increased prevalence of subclinical hypothyroidism (SCH) in patients with obesity. It is unclear if this biochemical abnormality may be a secondary phenomenon of obesity or a real hypothyroid state.

Methods A retrospective study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and November 2012 was performed. Weight loss, body mass index (BMI) and excess weight loss, baseline glucose, lipid profiles, and TSH levels were obtained before operation and postoperative determinations at 3, 6, and 12 months after surgery.

Results Sixty patients were included. Prevalence of subclinical hypothyroidism was 16.7 % preoperatively, 10 % at 3 months, 3.3 % at 6 months, and 1.7 % at 12 months. A significant correlation could be

established between TSH decrease and weight loss at 12 months (Pearson 0.603; p = 0.007). TSH decrease showed a significant AZD1208 correlation with glucose and glycated hemoglobin decrease from 6th month onwards. Referring to lipid profile, an association of TSH decrease with total cholesterol, LDL cholesterol, or HDL cholesterol could not be determined. A significant association between TSH decrease and triglycerides and cardiovascular risk index triglycerides/HDL cholesterol click here reductions could also be established 12 months after surgery.

Conclusions SCH is usually corrected after bariatric surgery, while there are no significant changes in total or LDL cholesterol. This

suggests that, in morbidly obese subjects, SCH is, in most patients, just a consequence of the abnormal fat accumulation and not a real hypothyroid state.”
“This study was conducted to assess the allelopathic effect of essential oils (EOs) obtained from the aerial parts of two different ecotypes (ECTPs A and B) of Zataria multiflora Boiss. with the aim of evaluating their invitro germination and growth inhibition potential. Gas chromatography (GC) and GC-mass spectrometry (GC-MS) analysis of the oils revealed that carvacrol and linalool (77.4% and 90.6%) were the two major oil components in ECTPs A and B, respectively, which were regarded as two different chemotypes. Other important volatile compounds found in ECTP A were -pinene (2.7%), p-cymene (7.9%) and -terpinene (3.5%). However, in ECTP B these compounds were in lesser amounts and -terpinene was not detected.