The velocity vector imaging measurements were repeated in 10 subjects by the same observer and a second observer to determine the intra-observer and then inter-observer correlations. Both of the observers were blinded to subjects data. Statistical analysis The SPSS version 13.0 software (SPSS Inc., Chicago, IL, USA) was used for the statistical analyses. Categorical data were expressed as frequencies. Continuous data were expressed as mean ± standard deviation. Comparison of continuous variables was performed by paired #HTS keyword# t-test. Comparison of categorical variables was performed
by the chi-square test. Correlation between velocity vector imaging parameters and other data was tested by Spearman correlation coefficients. Linear stepwise regression was performed to assess the adjusted association. Statistical significance was defined as p <0.05. Interclass correlation coefficient was used for evaluation of reproducibility. Results Patient
Inhibitors,research,lifescience,medical characteristics The basic characteristics of the groups are shown in Table 1. Systolic blood pressure, heart rate, BUN and creatinine post kidney transplantation were significantly lower than pre kidney transplantation (p < 0.05). Glucose Inhibitors,research,lifescience,medical was higher than pre kidney transplantation (p < 0.05). The distribution of cardioactive drugs was not statistically significant different pre- and post kidney transplantation. The noted change were that only two patients were on erythropoiesis stimulating agent after transplantation, compared with 52% of those before transplantation and all the patients were on immueosuppressive agents after transplantation. There was no significant difference in hemoglobin pre and post kidney transplantation (p > 0.05). Table 1 Comparison of clinical data pre and post kidney transplantation Inhibitors,research,lifescience,medical Conventional echocardiography LVEF, ratio of mitral early and late diastolic filling velocity, and LV rotation, twist and torsion were increased significantly post kidney transplantation compared to pre
kidney transplantation (p Inhibitors,research,lifescience,medical < 0.05) (Table 2). Interventricular septum thickness, left ventricular mass index, systolic blood pressure, serum blood urea nitrogen and creatinine were decreased significantly post kidney transplantation compared to pre kidney transplantation (p < 0.05). There was no significant difference pre and post kidney transplantation in RWtd (p > 0.05) (Table 2). Based on data in Table 2, LV displayed concentric hypertrophy Drug_discovery pre and post kidney transplantation in end stage renal disease. Table 2 Anatomical and functional indexes of left ventricle pre and post kidney transplantation Velocity vector imaging Post kidney transplantation peak rotation of apical LV (ROT-API), peak rotation of basal LV (ROT-BAS), peak twist (TW) and peak torsion of LV (TOR) were significantly higher than pre kidney transplantation (p < 0.05) (Fig. 1, Table 2). There was no significant difference between absolute value of ROT-BAS and ROT-API (p > 0.05).